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• W2329123585 abstract "Chronic treatment with the dopamine D2/D3 agonist, quinpirole, or the serotonin 1A agonist, 8-hydroxy-2-(di- n -propylamino)-tetralin (8-OH-DPAT), induces behavioral sensitization. It is not known whether both drugs produce sensitization through a shared mechanism. Here, we examine whether quinpirole and 8-OH-DPAT show cross-sensitization and impact sensitization, as would be expected from shared mechanisms. Male rats ( N =208) were assigned randomly to 16 groups formed by crossing four doses of quinpirole (0, 0.03125, 0.0625, or 0.125 mg/kg) with four doses of 8-OH-DPAT (0, 0.03125, 0.625, or 0.125 mg/kg). After a course of 10 drug treatments administered twice per week in locomotor activity chambers, all groups were challenged on separate tests with quinpirole (0.1 mg/kg), 8-OH-DPAT (0.1 mg/kg), or saline, and locomotor activity was evaluated. Challenge tests with quinpirole and 8-OHDPAT showed no cross-sensitization between the drugs. Chronic quinpirole (0.125 mg/kg) administration induced a sensitized quinpirole response that was attenuated dose-dependently by chronic 8-OH-DPAT cotreatment. Cotreatment with quinpirole (0.0625 mg/kg) and 8-OH-DPAT (all doses) induced quinpirole sensitization. Chronic 8-OH-DPAT (0.125 mg/kg) induced a sensitized 8-OHDPAT response that was prevented by chronic cotreatment with the lowest but not the highest dose of quinpirole. Cotreatment with 8-OHDPAT (0.0625) and quinpirole (0.125 mg/kg) induced sensitization to 8-OH-DPAT. The saline challenge test showed elevated locomotor activity in chronic quinpirole (0.125 mg/kg) and 8-OHDPAT (0.0625, 0.125 mg/kg) alone groups, and in seven of nine cotreated groups. The absence of cross-sensitization suggests separate mechanisms of sensitization to quinpirole and 8-OH-DPAT. Cotreatment effects suggest that induction of sensitization can be modulated by serotonin 1A and D2/D3 activity." @default.
• W2329123585 created "2016-06-24" @default.
• W2329123585 creator A5075170543 @default.
• W2329123585 creator A5090868883 @default.
• W2329123585 date "2016-08-01" @default.
• W2329123585 modified "2023-10-18" @default.
• W2329123585 title "A dose–response study of separate and combined effects of the serotonin agonist 8-OH-DPAT and the dopamine agonist quinpirole on locomotor sensitization, cross-sensitization, and conditioned activity" @default.
• W2329123585 cites W14465960 @default.
• W2329123585 cites W1593959100 @default.
• W2329123585 cites W1872057083 @default.
• W2329123585 cites W1913013241 @default.
• W2329123585 cites W1964310238 @default.
• W2329123585 cites W1968912840 @default.
• W2329123585 cites W1970174017 @default.
• W2329123585 cites W1978292464 @default.
• W2329123585 cites W1978609343 @default.
• W2329123585 cites W1983328853 @default.
• W2329123585 cites W1986884363 @default.
• W2329123585 cites W1988214379 @default.
• W2329123585 cites W1988222399 @default.
• W2329123585 cites W1990549633 @default.
• W2329123585 cites W1992963529 @default.
• W2329123585 cites W1992991774 @default.
• W2329123585 cites W1994429247 @default.
• W2329123585 cites W1995493882 @default.
• W2329123585 cites W1998489561 @default.
• W2329123585 cites W2001655948 @default.
• W2329123585 cites W2002926056 @default.
• W2329123585 cites W2005644211 @default.
• W2329123585 cites W2008145176 @default.
• W2329123585 cites W2014364106 @default.
• W2329123585 cites W2016437478 @default.
• W2329123585 cites W2016772251 @default.
• W2329123585 cites W2018376764 @default.
• W2329123585 cites W2018542375 @default.
• W2329123585 cites W2020482953 @default.
• W2329123585 cites W2027720642 @default.
• W2329123585 cites W2030984437 @default.
• W2329123585 cites W2032578858 @default.
• W2329123585 cites W2036322668 @default.
• W2329123585 cites W2041778878 @default.
• W2329123585 cites W2047706936 @default.
• W2329123585 cites W2048213004 @default.
• W2329123585 cites W2052008849 @default.
• W2329123585 cites W2057425568 @default.
• W2329123585 cites W2061344417 @default.
• W2329123585 cites W2070290419 @default.
• W2329123585 cites W2072923353 @default.
• W2329123585 cites W2074556443 @default.
• W2329123585 cites W2075029762 @default.
• W2329123585 cites W2076885963 @default.
• W2329123585 cites W2081808743 @default.
• W2329123585 cites W2083559639 @default.
• W2329123585 cites W2086177468 @default.
• W2329123585 cites W2090130900 @default.
• W2329123585 cites W2091048039 @default.
• W2329123585 cites W2091126291 @default.
• W2329123585 cites W2091383378 @default.
• W2329123585 cites W2091738137 @default.
• W2329123585 cites W2094897512 @default.
• W2329123585 cites W2097744565 @default.
• W2329123585 cites W2103880802 @default.
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• W2329123585 cites W2130835333 @default.
• W2329123585 cites W2143518315 @default.
• W2329123585 cites W2148364002 @default.
• W2329123585 cites W2163015549 @default.
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• W2329123585 doi "https://doi.org/10.1097/fbp.0000000000000219" @default.
• W2329123585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26871406" @default.
• W2329123585 hasPublicationYear "2016" @default.
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