Matches in SemOpenAlex for { <https://semopenalex.org/work/W2329127732> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2329127732 abstract "Mizolastine is a new peripherally acting histamine H1 receptor antagonist, which is metabolized by the liver both through conjugation and by cytochrome-P450 (CYP). It is reported that aging affects the pharmacokinetics of some drugs metabolized by the liver. Therefore, we performed a parallel group comparison of the pharmacokinetics of mizolastine in elderly and young subjects. The subjects were 12 apparently healthy male volunteers (6 elderly subjects aged 65 to 67 years and 6 younger subjects aged 20 to 24 years). Each subject was administered a tablet containing 10 mg of mizolastine at 9: 00 in the morning following an overnight fast. Blood sampling for the determination of plasma concentration of mizolastine was performed at 0.5, 1, 2, 3, 4, 6, 8, 12 and 24 hours after mizolastine administration. Mizolastine was well tolerated by the younger subjects, while symptoms such as sleepiness were noted by the elderly. The plasma concentration of mizolastine was higher in the elderly than in the young (p=0.010, a group effect by repeated measured ANOVA). The maximum plasma concentration (Cmax) was higher in the elderly (283.8±44.0 vs 222.2±30.1 ng/ml: elderly vs young, mean±S. D., p=0.018 by t-test) and area under the curve for 24 hours (AUC (0→24 hr)) was also larger in the elderly (2308±472 vs 1527±398 ng·hr/ml, p=0.011). Although time to reach Cmax was identical in the two groups, the elimination half life (t1/2) was longer in the elderly (8.8±1.9 vs 6.4±1.3 hours, p=0.030). It is considered that a change in the dosage regimen is not needed in the elderly, as the increase in the plasma concentration among elder subjects was about 50%, however careful observation of the subjective symptoms is desirable since sleepiness was only found in the elderly." @default.
- W2329127732 created "2016-06-24" @default.
- W2329127732 creator A5010589706 @default.
- W2329127732 creator A5013567557 @default.
- W2329127732 creator A5040189283 @default.
- W2329127732 creator A5042799172 @default.
- W2329127732 creator A5056752884 @default.
- W2329127732 creator A5067424481 @default.
- W2329127732 creator A5077640182 @default.
- W2329127732 creator A5090977580 @default.
- W2329127732 date "1998-01-01" @default.
- W2329127732 modified "2023-10-04" @default.
- W2329127732 title "Pharmacokinetics of Mizolastine (MKC-431), a Novel Antiallergic Drug, in the Elderly." @default.
- W2329127732 cites W1986812658 @default.
- W2329127732 cites W1991646353 @default.
- W2329127732 cites W1999288881 @default.
- W2329127732 cites W2004038693 @default.
- W2329127732 cites W2011241344 @default.
- W2329127732 cites W2022532320 @default.
- W2329127732 cites W2048624860 @default.
- W2329127732 cites W2057649516 @default.
- W2329127732 cites W2059266665 @default.
- W2329127732 cites W2062847583 @default.
- W2329127732 cites W2070167969 @default.
- W2329127732 cites W2081190121 @default.
- W2329127732 cites W2083498095 @default.
- W2329127732 cites W2284531888 @default.
- W2329127732 cites W2298869893 @default.
- W2329127732 cites W2302958003 @default.
- W2329127732 doi "https://doi.org/10.3999/jscpt.29.699" @default.
- W2329127732 hasPublicationYear "1998" @default.
- W2329127732 type Work @default.
- W2329127732 sameAs 2329127732 @default.
- W2329127732 citedByCount "0" @default.
- W2329127732 crossrefType "journal-article" @default.
- W2329127732 hasAuthorship W2329127732A5010589706 @default.
- W2329127732 hasAuthorship W2329127732A5013567557 @default.
- W2329127732 hasAuthorship W2329127732A5040189283 @default.
- W2329127732 hasAuthorship W2329127732A5042799172 @default.
- W2329127732 hasAuthorship W2329127732A5056752884 @default.
- W2329127732 hasAuthorship W2329127732A5067424481 @default.
- W2329127732 hasAuthorship W2329127732A5077640182 @default.
- W2329127732 hasAuthorship W2329127732A5090977580 @default.
- W2329127732 hasBestOaLocation W23291277321 @default.
- W2329127732 hasConcept C112705442 @default.
- W2329127732 hasConcept C126322002 @default.
- W2329127732 hasConcept C19720800 @default.
- W2329127732 hasConcept C22979827 @default.
- W2329127732 hasConcept C2988731192 @default.
- W2329127732 hasConcept C71924100 @default.
- W2329127732 hasConcept C90924648 @default.
- W2329127732 hasConcept C98274493 @default.
- W2329127732 hasConcept C99476002 @default.
- W2329127732 hasConceptScore W2329127732C112705442 @default.
- W2329127732 hasConceptScore W2329127732C126322002 @default.
- W2329127732 hasConceptScore W2329127732C19720800 @default.
- W2329127732 hasConceptScore W2329127732C22979827 @default.
- W2329127732 hasConceptScore W2329127732C2988731192 @default.
- W2329127732 hasConceptScore W2329127732C71924100 @default.
- W2329127732 hasConceptScore W2329127732C90924648 @default.
- W2329127732 hasConceptScore W2329127732C98274493 @default.
- W2329127732 hasConceptScore W2329127732C99476002 @default.
- W2329127732 hasLocation W23291277321 @default.
- W2329127732 hasOpenAccess W2329127732 @default.
- W2329127732 hasPrimaryLocation W23291277321 @default.
- W2329127732 hasRelatedWork W1782910219 @default.
- W2329127732 hasRelatedWork W1975982814 @default.
- W2329127732 hasRelatedWork W1990837595 @default.
- W2329127732 hasRelatedWork W1999386753 @default.
- W2329127732 hasRelatedWork W2006773204 @default.
- W2329127732 hasRelatedWork W2025968447 @default.
- W2329127732 hasRelatedWork W2036077705 @default.
- W2329127732 hasRelatedWork W2039642081 @default.
- W2329127732 hasRelatedWork W2045107630 @default.
- W2329127732 hasRelatedWork W2065005216 @default.
- W2329127732 hasRelatedWork W2078186665 @default.
- W2329127732 hasRelatedWork W2095427741 @default.
- W2329127732 hasRelatedWork W2120066687 @default.
- W2329127732 hasRelatedWork W2141139498 @default.
- W2329127732 hasRelatedWork W2313591697 @default.
- W2329127732 hasRelatedWork W2315935958 @default.
- W2329127732 hasRelatedWork W2325251142 @default.
- W2329127732 hasRelatedWork W2329748984 @default.
- W2329127732 hasRelatedWork W2460378176 @default.
- W2329127732 hasRelatedWork W2948894715 @default.
- W2329127732 isParatext "false" @default.
- W2329127732 isRetracted "false" @default.
- W2329127732 magId "2329127732" @default.
- W2329127732 workType "article" @default.