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- W2329128932 abstract "To exploit the potential antimicrobial activities of azabicyclic skeleton based compounds, a set of 2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-one-4-methyl-1,2,3-thiadazole-5-carbonyl hydrazones were synthesized. Unambiguous structural elucidation has been carried out by investigating IR, H1, C13 NMR, and elemental analysis. 2D NMR spectra (1H–1H COSY, HSQC, HMBC, and NOESY) were recorded for a representative compound, 12, to confirm the proposed structure for 9–15. Antimicrobial activity assessment of synthesized hydrazones 9–15 has been evaluated by screening against selective strains. Both bacteria and fungi of various forms along with standard drug have been taken for the analysis. Difference in the potency of activity against the strains has been evaluated on the basis of SAR, and it has been revealed that substitution of electron-withdrawing halogens (chloro, fluoro, and bromo) at para positions of the phenyl (10, 12, and 13) enhanced the antifungal and antibacterial activities against tested organisms compared to other hydrazone derivatives." @default.
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- W2329128932 date "2013-11-27" @default.
- W2329128932 modified "2023-10-17" @default.
- W2329128932 title "Antimicrobial Evaluation of a Set of Heterobicyclic Methylthiadiazole Hydrazones: Synthesis, Characterization, and SAR Studies" @default.
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- W2329128932 doi "https://doi.org/10.1021/jf404537d" @default.
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