FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2329150886> ?p ?o ?g. }

• W2329150886 endingPage "A20" @default.
• W2329150886 startingPage "A19.3" @default.
• W2329150886 abstract "<h3>Background and Objectives</h3> CD8⁺T cells are known to be present in the synovial fluid and synovium of rheumatoid arthritis. However, their role in the disease pathogenesis remains largely unexplored. This work intended to characterise blood and synovial fluid CD8⁺T cell functional subsets found in patients with rheumatoid arthritis and explore their importance in regulating the activity of the disease. <h3>Methods</h3> The functional phenotypes of CD8⁺T cells were determined in seventy-eight patients with rheumatoid arthritis (forty-four in remission (DAS28 < 2.6), thirty-four with active disease (DAS28 > 3.2)) and the results were compared to those of sixty-four sex and age-matched healthy controls (HC). Ten paired samples of blood and synovial fluid (SF) from patients with active disease were also analysed, and the expression of surface markers, cytokines and proteolytic enzymes of CD8⁺T cells were determined. <h3>Results</h3> Data shows that peripheral blood CD8⁺T cells from both patients with active disease and in remission present an activated phenotype with a marked pro-inflammatory profile. Remission is associated with a lower production of proinflammatory mediators, such as IL-6 and IFNγ, but the changes in cell subsets observed in active disease persist or are even accentuated, with the frequency of the central memory CD27⁺CD62L⁺CCR7⁺CD8⁺T cells significantly reduced, and the short-term effector CD27^-CD62L^-CD8⁺and the activated subset CD69⁺CD8⁺ T cell subsets significantly increased when compared to healthy controls. The CD8⁺T cells present in the SF of active RA present a more exacerbated effector memory (CD27⁺CD62L^-) and activated (CD25⁺and CD69⁺) CD8⁺T cell phenotype than the ones in the paired blood samples. Finally, we report that the production of cytokines by CD8⁺T cells from the synovial fluid is correlated with that observed in peripheral blood samples, with increased production of proinflammatory cytokines such as IL-6 and TNFα. <h3>Conclusions</h3> Our data demonstrate major shifts in CD8⁺T cells subsets and in their cytokine production in rheumatoid arthritis, which are related to disease activity. This suggests that these cells play relevant roles in the pathogenesis of the disease." @default.
• W2329150886 created "2016-06-24" @default.
• W2329150886 creator A5008274472 @default.
• W2329150886 creator A5027905213 @default.
• W2329150886 creator A5031649617 @default.
• W2329150886 creator A5059601670 @default.
• W2329150886 creator A5077382284 @default.
• W2329150886 date "2014-01-31" @default.
• W2329150886 modified "2023-09-26" @default.
• W2329150886 title "A1.46 CD8+T cell profiles in patients with rheumatoid arthritis and their relation with disease activity" @default.
• W2329150886 doi "https://doi.org/10.1136/annrheumdis-2013-205124.45" @default.
• W2329150886 hasPublicationYear "2014" @default.
• W2329150886 type Work @default.
• W2329150886 sameAs 2329150886 @default.
• W2329150886 citedByCount "0" @default.
• W2329150886 crossrefType "journal-article" @default.
• W2329150886 hasAuthorship W2329150886A5008274472 @default.
• W2329150886 hasAuthorship W2329150886A5027905213 @default.
• W2329150886 hasAuthorship W2329150886A5031649617 @default.
• W2329150886 hasAuthorship W2329150886A5059601670 @default.
• W2329150886 hasAuthorship W2329150886A5077382284 @default.
• W2329150886 hasConcept C126322002 @default.
• W2329150886 hasConcept C142724271 @default.
• W2329150886 hasConcept C147483822 @default.
• W2329150886 hasConcept C164027704 @default.
• W2329150886 hasConcept C167672396 @default.
• W2329150886 hasConcept C203014093 @default.
• W2329150886 hasConcept C204787440 @default.
• W2329150886 hasConcept C2776090121 @default.
• W2329150886 hasConcept C2776164576 @default.
• W2329150886 hasConcept C2776268809 @default.
• W2329150886 hasConcept C2776914184 @default.
• W2329150886 hasConcept C2777077863 @default.
• W2329150886 hasConcept C2777575956 @default.
• W2329150886 hasConcept C2777652487 @default.
• W2329150886 hasConcept C71924100 @default.
• W2329150886 hasConcept C8891405 @default.
• W2329150886 hasConceptScore W2329150886C126322002 @default.
• W2329150886 hasConceptScore W2329150886C142724271 @default.
• W2329150886 hasConceptScore W2329150886C147483822 @default.
• W2329150886 hasConceptScore W2329150886C164027704 @default.
• W2329150886 hasConceptScore W2329150886C167672396 @default.
• W2329150886 hasConceptScore W2329150886C203014093 @default.
• W2329150886 hasConceptScore W2329150886C204787440 @default.
• W2329150886 hasConceptScore W2329150886C2776090121 @default.
• W2329150886 hasConceptScore W2329150886C2776164576 @default.
• W2329150886 hasConceptScore W2329150886C2776268809 @default.
• W2329150886 hasConceptScore W2329150886C2776914184 @default.
• W2329150886 hasConceptScore W2329150886C2777077863 @default.
• W2329150886 hasConceptScore W2329150886C2777575956 @default.
• W2329150886 hasConceptScore W2329150886C2777652487 @default.
• W2329150886 hasConceptScore W2329150886C71924100 @default.
• W2329150886 hasConceptScore W2329150886C8891405 @default.
• W2329150886 hasIssue "Suppl 1" @default.
• W2329150886 hasLocation W23291508861 @default.
• W2329150886 hasOpenAccess W2329150886 @default.
• W2329150886 hasPrimaryLocation W23291508861 @default.
• W2329150886 hasRelatedWork W1882900263 @default.
• W2329150886 hasRelatedWork W1979499339 @default.
• W2329150886 hasRelatedWork W1991393819 @default.
• W2329150886 hasRelatedWork W1998340618 @default.
• W2329150886 hasRelatedWork W2068097628 @default.
• W2329150886 hasRelatedWork W2104646232 @default.
• W2329150886 hasRelatedWork W2146517830 @default.
• W2329150886 hasRelatedWork W2255309363 @default.
• W2329150886 hasRelatedWork W2618751246 @default.
• W2329150886 hasRelatedWork W413831 @default.
• W2329150886 hasVolume "73" @default.
• W2329150886 isParatext "false" @default.
• W2329150886 isRetracted "false" @default.
• W2329150886 magId "2329150886" @default.
• W2329150886 workType "article" @default.