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• W2329188676 abstract "This article reports the application of in vitro multinuclear (19F and 1H) two-dimensional magnetic resonance imaging (MRI) to study both dissolution media ingress and drug egress from a commercial Lescol XL extended release tablet in a United States Pharmacopeia Type IV (USP-IV) dissolution cell under pharmacopoeial conditions. Noninvasive spatial maps of tablet swelling and dissolution, as well as the mobilization and distribution of the drug are quantified and visualized. Two-dimensional active pharmaceutical ingredient (API) mobilization and distribution maps were obtained via 19F MRI. 19F API maps were coregistered with 1H T2-relaxation time maps enabling the simultaneous visualization of drug distribution and gel layer dynamics within the swollen tablet. The behavior of the MRI data is also discussed in terms of its relationship to the UV drug release behavior." @default.
• W2329188676 created "2016-06-24" @default.
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• W2329188676 date "2014-01-03" @default.
• W2329188676 modified "2023-09-26" @default.
• W2329188676 title "Direct Visualization of <i>in Vitro</i> Drug Mobilization from Lescol XL Tablets Using Two-Dimensional ¹⁹F and ¹H Magnetic Resonance Imaging" @default.
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• W2329188676 doi "https://doi.org/10.1021/mp400407c" @default.
• W2329188676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24344634" @default.
• W2329188676 hasPublicationYear "2014" @default.
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