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- W2329327636 abstract "Background and aims: While mortality rates from pediatric critical illness are carefully monitored, proximate causes of death are not well understood. Aims: Our aim was to determine the impact of brain injury (BI) in children with congenital heart disease (CHD) who die in the intensive care setting and the role of these injuries in the cause of death. Methods: This was a retrospective cohort study conducted in a 14-bed pediatric cardiac ICU. We included all patients who died at our Institution from August 2010 to August 2013. The IRB approved the study and waived the requirement for written informed consent. BI was defined as hypoxic/ischemic, hemorrhage and herniation. Multivariable regression analyses were used to determine relationships between demographic and peri-operative patients variables and BI when recognized as proximate cause of death. Results: Fifty-four patients died during the study period. BI was present in 32 (59.2%) patients and was deemed as proximate cause of death in 14 (26%). Pre-existing BI (odds ratio (OR), 9.43; 95% CI, 1.44 to 61.5) nosocomial infection (OR, 7.29; 95% CI, 1.5 to 35.09) and age (OR, 1.01; 95% CI, 1.01 to 1.02) were associated with greater adjusted odds of developing a BI considered a proximate cause of death. Conclusions: BI was frequent in children who died in our ICU and was the proximate cause of death in a large proportion of cases. Appropriate risk stratification and prevention of nosocomial infections are likely to act as neuroprotective strategies that might help to further reduce mortality rates in children with CHD." @default.
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- W2329327636 date "2014-05-01" @default.
- W2329327636 modified "2023-10-18" @default.
- W2329327636 title "ABSTRACT 349" @default.
- W2329327636 doi "https://doi.org/10.1097/01.pcc.0000449075.04158.55" @default.
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