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- W2329353374 abstract "To evaluate Turkish physicians’ preferences when selecting between the different bone-targeted agents (BTAs) available for preventing skeletal-related events (SREs) in patients with bone metastases from advanced solid tumors. Physicians from several centres, currently treating patients with bone metastases from solid tumours were recruited by phone or personal invitation and then engaged in a face-to-face interview where they completed a web-enabled discrete-choice experiment survey. Each survey included 10 choices between pairs of hypothetical treatment profiles for the two putative patient profiles. The hypothetical treatment profiles included five attributes within a pre-defined range (based on prescribing information): time until first SRE (10,18 and 28 months); time until worsening of pain (3,6 and 10 months); annual risk of osteonecrosis of the jaw (ONJ; 0,1 and 5%); annual risk of renal impairment (0,4 and 10%); and mode of administration (oral tablet, subcutaneous injection, 15-minute or 120-minute intravenous infusion). Choice questions were based on an experimental design with known statistical properties. A main-effects random parameters logit model was estimated. A total of 105 physicians agreed to participate in the face-to-face interview and accessed the online survey. Of these, 104 physicians were eligible and consented to participate and 99 were included in the analysis. Estimated preference weights for all applicable attributes were consistent with the natural ordering of the categories. Risk of renal impairment and months until first SRE were the most important attributes influencing physicians’ decisions, with better clinical outcomes preferred to worse outcomes. Preventing pain progression was the third most important attribute followed by mode of administration. Annual risk of ONJ was the least important attribute. When making treatment decisions regarding choice of BTA for patients with bone metastases, the main treatment goals for Turkish physicians are reducing risk of renal impairment and delaying first SRE." @default.
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- W2329353374 date "2014-11-01" @default.
- W2329353374 modified "2023-09-28" @default.
- W2329353374 title "Physicians' Preferences for Bone Metastases Treatments in Turkey" @default.
- W2329353374 doi "https://doi.org/10.1016/j.jval.2014.08.1905" @default.
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