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- W2329361612 abstract "INTRODUCTION: Alterations in TNF-a expression have been associated with cerebral aneurysms, but a direct role in aneurysm formation and rupture has not been established. METHODS: Aneurysms were induced in mice by a combination of induced hypertension and a single stereotactic injection of elastase into the right basal cistern. To test the role of TNF-a in aneurysm formation, aneurysms were induced in TNF-a knock-out mice and mice pretreated with the synthesized TNF-a inhibitor 3,6'dithiothalidomide (DTH). Aneurysmal rupture was detected by alteration of neurological symptoms and confirmed by the presence of intracranial aneurysms with subarachnoid hemorrhage. TNF-a expression was assessed through real-time PCR and with immunofluorence staining. RESULTS: Cerebral aneurysm formation occurred in 18 of 22 (81.8%) animals receiving only vehicle as compared to 3 of 12 TNF-a knock-out mice receiving vehicle (25%, P = .002) and 4 of 12 mice (33%, P = .008) treated with DTH. TNF-a knock-out mice were 12.4 times (95% CI 1.6-94.2, P = .015) and those treated with DTH were 4.1 times (95% CI 1.2-14.1, P = .028) less likely to have aneurysm rupture as compared to those receiving vehicle only. As compared with untreated mice, TNF-a expression was not significantly different in TNF-a knock-out mice or those pre-treated with DTH, but was significantly elevated in unruptured and furthermore ruptured aneurysms. CONCLUSION: These data suggest a critical role of TNF-a in the formation and rupture of aneurysms in a model of cerebral aneurysm formation. Inhibitors of TNF-a could be beneficial in preventing aneurysm rupture." @default.
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- W2329361612 date "2013-08-01" @default.
- W2329361612 modified "2023-09-27" @default.
- W2329361612 title "190 Critical Role of TNF-a in Cerebral Aneurysm Formation and Rupture" @default.
- W2329361612 doi "https://doi.org/10.1227/01.neu.0000432780.74094.e2" @default.
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