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• W2329384916 abstract "We herein compared the effects of the chronic feeding of high-fat (HF), high-sucrose (HS), and low-fat/low-sucrose (control) diets on carcinogenesis following chronic ultraviolet B (UVB) irradiation in hairless mice. UVB irradiation-induced carcinogenesis was more prominent in HF diet-fed group than in control diet- and HS diet-fed groups. The HS diet group, as well as the HF diet one, showed tumor development and growth, increased skin matrix metalloproteinase (MMP) and blood plasminogen activator inhibitor-1 (PAI-1) levels, and decreased blood leptin and adiponectin levels after long-term UVB irradiation. These changes were smaller in the HS diet group than in the HF diet group. In addition, no difference was noted in the above changes between the control and HS diet groups. The increase induced in adipose tissue weight by the HF diet was markedly reduced by UVB irradiation. This result suggests that the abundant availability of lipids in hypertrophic adipose tissue may be related to tumor incidence and growth through increases in blood PAI-1 and skin MMP-9 expression levels and decreases in blood adiponectin levels by UVB irradiation. In conclusion, HF diet-induced hypertrophic adipose tissue is an important cancer risk factor that promotes UV irradiation-induced carcinogenesis and tumor growth." @default.
• W2329384916 created "2016-06-24" @default.
• W2329384916 creator A5018525351 @default.
• W2329384916 creator A5030209507 @default.
• W2329384916 date "2016-04-04" @default.
• W2329384916 modified "2023-10-14" @default.
• W2329384916 title "Effects of a High-Fat or High-Sucrose Diet on Ultraviolet B Irradiation-Induced Carcinogenesis and Tumor Growth in Melanin-Possessing Hairless Mice" @default.
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• W2329384916 doi "https://doi.org/10.1080/01635581.2016.1159703" @default.
• W2329384916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27046042" @default.
• W2329384916 hasPublicationYear "2016" @default.
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