FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2329408351> ?p ?o ?g. }

• W2329408351 endingPage "80" @default.
• W2329408351 startingPage "80.2" @default.
• W2329408351 abstract "<h3>Background</h3> Synovitis causes joint destruction in rheumatoid arthritis (RA). While FDG-PET illustrates synovitis sensitively, NaF-PET detects accelerated bone metabolism in osteoplastic lesions of osteoarthrists (OA) as well as osteolytic lesions. <h3>Objectives</h3> This study examined the relationship between inflammation and bone damages in joint lesions of RA by using 18F-FDG and 18F-NaF PET/CT of the hands. <h3>Methods</h3> Twelve RA patients who started to receive a new biologic agent (naïve 9, switch 3; Etanercept 4, Infliximab 2, Golimumab 2, Tocilizumab 3, Abatacept 1) were enrolled. The bilateral hands were examined by FDG-, NaF-PET/CT and MRI at the entry. Intensity of PET signals was determined by standardized uptake value max (SUVmax) in MCPs, PIPs, and ulnar, medial, and radial regions of the wrist. All joints were also evaluated by power doppler (PD) and gray scale (GS) scores (0-3) in ultrasonography (US). Total score of each parameter was determined by summing up of individual parameters in all joints. Hand X-rays were evaluated according to Genant-modified Sharp score at the baseline and 6 months later. Findings of these imaging modalities and clinical assessments were comparatively analyzed in individual joints. <h3>Results</h3> The SUVmax of FDG correlated with that of NaF in individual joints (r=0.62), though detail anatomical localizations were different between them (Figure 1). While NaF signals located on the bone, those of FDG were mainly found in the synovial brusa and tendons On the other hand, NaF accumulation was not accompanied by FDG signals in osteoplastic lesions which were diagnosed as complicated OA in X-ray. Both total FDG and total NaF scores correlated with total PD and total GS of US and DAS 28. Moreover, NaF scores also correlated with HAQ. Both FDG and NaF SUVmax were significant higher in 44 joints having progression of erosion score than the other 268 joints (FDG; p=0.004, NaF p<0.001). Moreover, total NaF, but not FDG, score was correlated with deterioration of total Sharp score (r=0.66). <h3>Conclusions</h3> FDG-PET detects synovistis sensitively, whereas NaF accumulation is more closely associated with bone destructive and plastic lesions. Simultaneous accumulation of the both molecules suggest coupling of inflammation and accelerated bone metabolism in RA joints. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2231" @default.
• W2329408351 created "2016-06-24" @default.
• W2329408351 creator A5005143589 @default.
• W2329408351 creator A5008733250 @default.
• W2329408351 creator A5009363901 @default.
• W2329408351 creator A5033913974 @default.
• W2329408351 creator A5034642477 @default.
• W2329408351 creator A5038531974 @default.
• W2329408351 creator A5044234649 @default.
• W2329408351 creator A5049189492 @default.
• W2329408351 creator A5064136261 @default.
• W2329408351 creator A5068324101 @default.
• W2329408351 creator A5074816610 @default.
• W2329408351 date "2014-06-01" @default.
• W2329408351 modified "2023-10-16" @default.
• W2329408351 title "OP0052 Prospective Evaluation of 18F-FDG and 18F-Naf Pet/Ct: Imaging Analysis of Inflammation and Bone Metabolism in Rheumatoid Arthritis" @default.
• W2329408351 cites W1952352286 @default.
• W2329408351 doi "https://doi.org/10.1136/annrheumdis-2014-eular.2231" @default.
• W2329408351 hasPublicationYear "2014" @default.
• W2329408351 type Work @default.
• W2329408351 sameAs 2329408351 @default.
• W2329408351 citedByCount "0" @default.
• W2329408351 crossrefType "journal-article" @default.
• W2329408351 hasAuthorship W2329408351A5005143589 @default.
• W2329408351 hasAuthorship W2329408351A5008733250 @default.
• W2329408351 hasAuthorship W2329408351A5009363901 @default.
• W2329408351 hasAuthorship W2329408351A5033913974 @default.
• W2329408351 hasAuthorship W2329408351A5034642477 @default.
• W2329408351 hasAuthorship W2329408351A5038531974 @default.
• W2329408351 hasAuthorship W2329408351A5044234649 @default.
• W2329408351 hasAuthorship W2329408351A5049189492 @default.
• W2329408351 hasAuthorship W2329408351A5064136261 @default.
• W2329408351 hasAuthorship W2329408351A5068324101 @default.
• W2329408351 hasAuthorship W2329408351A5074816610 @default.
• W2329408351 hasConcept C126322002 @default.
• W2329408351 hasConcept C126838900 @default.
• W2329408351 hasConcept C170033053 @default.
• W2329408351 hasConcept C2775842073 @default.
• W2329408351 hasConcept C2777077863 @default.
• W2329408351 hasConcept C2777226972 @default.
• W2329408351 hasConcept C2777575956 @default.
• W2329408351 hasConcept C2778216619 @default.
• W2329408351 hasConcept C2779244835 @default.
• W2329408351 hasConcept C2989005 @default.
• W2329408351 hasConcept C71924100 @default.
• W2329408351 hasConceptScore W2329408351C126322002 @default.
• W2329408351 hasConceptScore W2329408351C126838900 @default.
• W2329408351 hasConceptScore W2329408351C170033053 @default.
• W2329408351 hasConceptScore W2329408351C2775842073 @default.
• W2329408351 hasConceptScore W2329408351C2777077863 @default.
• W2329408351 hasConceptScore W2329408351C2777226972 @default.
• W2329408351 hasConceptScore W2329408351C2777575956 @default.
• W2329408351 hasConceptScore W2329408351C2778216619 @default.
• W2329408351 hasConceptScore W2329408351C2779244835 @default.
• W2329408351 hasConceptScore W2329408351C2989005 @default.
• W2329408351 hasConceptScore W2329408351C71924100 @default.
• W2329408351 hasIssue "Suppl 2" @default.
• W2329408351 hasLocation W23294083511 @default.
• W2329408351 hasOpenAccess W2329408351 @default.
• W2329408351 hasPrimaryLocation W23294083511 @default.
• W2329408351 hasRelatedWork W145086642 @default.
• W2329408351 hasRelatedWork W1997363697 @default.
• W2329408351 hasRelatedWork W2104646232 @default.
• W2329408351 hasRelatedWork W2379622864 @default.
• W2329408351 hasRelatedWork W2407701778 @default.
• W2329408351 hasRelatedWork W2441992926 @default.
• W2329408351 hasRelatedWork W2801007752 @default.
• W2329408351 hasRelatedWork W2910493901 @default.
• W2329408351 hasRelatedWork W2920223959 @default.
• W2329408351 hasRelatedWork W78488825 @default.
• W2329408351 hasVolume "73" @default.
• W2329408351 isParatext "false" @default.
• W2329408351 isRetracted "false" @default.
• W2329408351 magId "2329408351" @default.
• W2329408351 workType "article" @default.