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- W2329410316 abstract "A murine IgM monoclonal antibody termed Wm-66 has been produced which binda to a novel uncluttered 65 Kitodalton leucocyte surface membrane antigen present on virtually all normal lymphocytes and monocytei. This antibody has been shown to react strongly with most types of chronic B cell malignancies (CLL and NHL) and to kill target cells in the presence of human complement. These properties suggested a potential role for WM-66 as a therapeutic agent in CLL and lymphoma. The antibody was prepared in mice as ascitet, separated by gel filtration and hydroxylapatite chromatography to 88% purity, and checked for immunoreactivity, sterility, and pyrogenicity. A 59 year old male with advanced refractory well-differentiated lymphocytic lymphoma in leukaemic phase was selected for treatment with WM-66 He had generalised lymphadenopathy and 19cms palpable splenomegaly Antibody was infused daily intravenously in saline over 1-2 hrs in increasing doses up to 30 mg with a total of 65 mg given in 5 days No significant toxic side effects were seen. The peripheral blood white cell count, initially 68 × 10 9 /L (90% lymphocytes), fell by 25-50% immediately after each infusion, although with some rebound by 24 hours, reaching a minimum of 34 × 10 9 /L at the completion of treatment Leucocytes showed coating with mouse immunoglobulin after the 20 mg and 30 mg doses. The spleen sise was recuded to 14 cms after 5 days. We conclude that WM-66 antibody produces cytoreduction when infused intravenously in a patient with NHL without evidence of toxicity Further studies with higher doses and different schedules are planned." @default.
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- W2329410316 date "1991-01-01" @default.
- W2329410316 modified "2023-09-27" @default.
- W2329410316 title "In vivo therapy of non hodgkins lymphoma with a cytotoxic murine monoclonal antibody; a preliminary report" @default.
- W2329410316 doi "https://doi.org/10.1016/s0031-3025(16)36210-9" @default.
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