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• W2329421701 startingPage "158" @default.
• W2329421701 abstract "It has long been believed that most of drugs are absorbed by passive diffusion mechanism. However, some drugs have been suggested to be absorbed by specialized transporters, although no clear evidence for the involvement of such membrane transport mechanisms has been obtained. In the present study, carrier-mediated transport mechanisms involved in the drug absorption was clarified by the approach of molecular cloning and functional expression of the transporters as well as membrane physiological analysis of drug transport. pH-Dependent intestinal absorption of monocarboxylic acids was demonstrated to be partially ascribed to the monocarboxylic acid-proton cotransporter, MCT1 and pH-sensitive anion antiporter AE2. An involvement of such pH-dependent transporters in the intestinal absorption of weak organic acids is important, because they can be alternative mechanisms against passive diffusion according to pH-partition hypothesis. PepT1 cloned from intestinal epithelial cells as the peptide transporter was clarified to be utilized for the enhanced intestinal absorption of peptide-mimetics such as β-lactam antibiotics and others by a proton-gradient dependent mechanism. In contrast, P-glycoprotein decreases apparent intestinal absorption of various drugs by its secretory transport activity into intestinal lumen, thereby causing nonlinear phenomena in intestinal absorption kinetics. These lines of studies of the clarification of carrier-mediated drug absorption mechanisms will provide a new knowledge for the targets and strategies in controlling intestinal absorption of drugs." @default.
• W2329421701 created "2016-06-24" @default.
• W2329421701 creator A5026770912 @default.
• W2329421701 date "1999-01-01" @default.
• W2329421701 modified "2023-09-27" @default.
• W2329421701 title "Molecular Mechanisms of Intestinal Absorptive and Secretory Transports of Drugs." @default.
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• W2329421701 doi "https://doi.org/10.2133/dmpk.14.158" @default.
• W2329421701 hasPublicationYear "1999" @default.
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