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- W2329474013 abstract "This study investigates the effects and possible mechanism of coenzyme Q10 (CoQ10) on endogenous glutamate release in the cerebral cortex nerve terminals of rats. CoQ10 inhibited the release of glutamate evoked by the K+ channel blocker 4-aminopyridine (4-AP). CoQ10 reduced the depolarization-induced increase in cytosolic [Ca2+]c but did not alter the 4-AP-mediated depolarization. The effect of CoQ10 on evoked glutamate release was abolished by blocking the Cav2.2 (N-type) and Cav2.1 (P/Q-type) Ca2+ channels and mitogen-activated protein kinase kinase (MEK). In addition, CoQ10 decreased the 4-AP-induced phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and synaptic vesicle-associated protein synapsin I, a major presynaptic substrate for ERK. Moreover, the inhibition of glutamate release by CoQ10 was strongly attenuated in mice without synapsin I. These results suggest that CoQ10 inhibits glutamate release from cortical synaptosomes in rats through the suppression of the presynaptic voltage-dependent Ca2+ entry and ERK/synapsin I signaling pathway." @default.
- W2329474013 created "2016-06-24" @default.
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- W2329474013 creator A5048996459 @default.
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- W2329474013 date "2012-11-20" @default.
- W2329474013 modified "2023-10-01" @default.
- W2329474013 title "Coenzyme Q10 Inhibits the Release of Glutamate in Rat Cerebrocortical Nerve Terminals by Suppression of Voltage-Dependent Calcium Influx and Mitogen-Activated Protein Kinase Signaling Pathway" @default.
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- W2329474013 doi "https://doi.org/10.1021/jf302875k" @default.
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