FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2329510256> ?p ?o ?g. }

• W2329510256 endingPage "808" @default.
• W2329510256 startingPage "803" @default.
• W2329510256 abstract "Objective Uterine leiomyosarcoma (LMS) has an unfavorable response to standard chemotherapy. A natural occurring compound, curcumin, has been shown to have inhibitory effects on cancers. We previously demonstrated that curcumin reduced uterine LMS cell proliferation by targeting the AKT-mTOR pathway and activating apoptosis. To further explore the anticancer effect of curcumin, we investigated the efficacy of curcumin on autophagy in LMS cells. Methods Cell proliferation in human uterine LMS cell lines, SKN and SK-UT-1, was assessed after exposure to rapamycin or curcumin. Autophagy was detected by Western blotting for light chain 3 and sequestosome 1 (SQSTM1/p62) expression. Apoptosis was confirmed by Western blotting for cleaved poly (ADP-ribose) polymerase (PARP). Results Both rapamycin and curcumin potently inhibited SKN and SK-UT-1 cell proliferation in a dose-dependent manner. Curcumin induced autophagy and apoptosis in SKN and SK-UT-1 cells, whereas rapamycin, a specific mTOR inhibitor, did not. Curcumin increased extracellular signal-regulated kinase 1/2 activity in both SKN and SK-UT-1 cells, whereas PD98059, an MEK1 inhibitor, inhibited both the extracellular signal-regulated kinase 1/2 pathway and curcumin-induced autophagy. Conclusions These experimental findings suggest that curcumin is a potent inhibitor of cell proliferation in uterine LMS and provide new insights about ongoing signaling events leading to the possible development of a new therapeutic agent." @default.
• W2329510256 created "2016-06-24" @default.
• W2329510256 creator A5004955803 @default.
• W2329510256 creator A5009399227 @default.
• W2329510256 creator A5018689604 @default.
• W2329510256 creator A5055669934 @default.
• W2329510256 creator A5059839264 @default.
• W2329510256 creator A5074243718 @default.
• W2329510256 creator A5081741121 @default.
• W2329510256 creator A5083544452 @default.
• W2329510256 date "2013-06-01" @default.
• W2329510256 modified "2023-10-18" @default.
• W2329510256 title "Curcumin Induces Cross-Regulation Between Autophagy and Apoptosis in Uterine Leiomyosarcoma Cells" @default.
• W2329510256 cites W1963521777 @default.
• W2329510256 cites W1972761807 @default.
• W2329510256 cites W1981122961 @default.
• W2329510256 cites W2003830975 @default.
• W2329510256 cites W2017813632 @default.
• W2329510256 cites W2018636808 @default.
• W2329510256 cites W2019293853 @default.
• W2329510256 cites W2019390346 @default.
• W2329510256 cites W2021484735 @default.
• W2329510256 cites W2037175822 @default.
• W2329510256 cites W2047069988 @default.
• W2329510256 cites W2058996967 @default.
• W2329510256 cites W2064136894 @default.
• W2329510256 cites W2069693587 @default.
• W2329510256 cites W2082479412 @default.
• W2329510256 cites W2105998600 @default.
• W2329510256 cites W2133291429 @default.
• W2329510256 cites W2137631271 @default.
• W2329510256 cites W2138508372 @default.
• W2329510256 cites W2138888192 @default.
• W2329510256 cites W2140377151 @default.
• W2329510256 cites W2140813472 @default.
• W2329510256 cites W2143728373 @default.
• W2329510256 doi "https://doi.org/10.1097/igc.0b013e31828c9581" @default.
• W2329510256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23532091" @default.
• W2329510256 hasPublicationYear "2013" @default.
• W2329510256 type Work @default.
• W2329510256 sameAs 2329510256 @default.
• W2329510256 citedByCount "39" @default.
• W2329510256 countsByYear W23295102562013 @default.
• W2329510256 countsByYear W23295102562014 @default.
• W2329510256 countsByYear W23295102562015 @default.
• W2329510256 countsByYear W23295102562016 @default.
• W2329510256 countsByYear W23295102562017 @default.
• W2329510256 countsByYear W23295102562018 @default.
• W2329510256 countsByYear W23295102562019 @default.
• W2329510256 countsByYear W23295102562020 @default.
• W2329510256 countsByYear W23295102562021 @default.
• W2329510256 countsByYear W23295102562022 @default.
• W2329510256 countsByYear W23295102562023 @default.
• W2329510256 crossrefType "journal-article" @default.
• W2329510256 hasAuthorship W2329510256A5004955803 @default.
• W2329510256 hasAuthorship W2329510256A5009399227 @default.
• W2329510256 hasAuthorship W2329510256A5018689604 @default.
• W2329510256 hasAuthorship W2329510256A5055669934 @default.
• W2329510256 hasAuthorship W2329510256A5059839264 @default.
• W2329510256 hasAuthorship W2329510256A5074243718 @default.
• W2329510256 hasAuthorship W2329510256A5081741121 @default.
• W2329510256 hasAuthorship W2329510256A5083544452 @default.
• W2329510256 hasConcept C184235292 @default.
• W2329510256 hasConcept C190283241 @default.
• W2329510256 hasConcept C203522944 @default.
• W2329510256 hasConcept C2778250585 @default.
• W2329510256 hasConcept C502942594 @default.
• W2329510256 hasConcept C55493867 @default.
• W2329510256 hasConcept C62112901 @default.
• W2329510256 hasConcept C62478195 @default.
• W2329510256 hasConcept C71924100 @default.
• W2329510256 hasConcept C75217442 @default.
• W2329510256 hasConcept C86554907 @default.
• W2329510256 hasConcept C86803240 @default.
• W2329510256 hasConcept C95444343 @default.
• W2329510256 hasConcept C98274493 @default.
• W2329510256 hasConceptScore W2329510256C184235292 @default.
• W2329510256 hasConceptScore W2329510256C190283241 @default.
• W2329510256 hasConceptScore W2329510256C203522944 @default.
• W2329510256 hasConceptScore W2329510256C2778250585 @default.
• W2329510256 hasConceptScore W2329510256C502942594 @default.
• W2329510256 hasConceptScore W2329510256C55493867 @default.
• W2329510256 hasConceptScore W2329510256C62112901 @default.
• W2329510256 hasConceptScore W2329510256C62478195 @default.
• W2329510256 hasConceptScore W2329510256C71924100 @default.
• W2329510256 hasConceptScore W2329510256C75217442 @default.
• W2329510256 hasConceptScore W2329510256C86554907 @default.
• W2329510256 hasConceptScore W2329510256C86803240 @default.
• W2329510256 hasConceptScore W2329510256C95444343 @default.
• W2329510256 hasConceptScore W2329510256C98274493 @default.
• W2329510256 hasIssue "5" @default.
• W2329510256 hasLocation W23295102561 @default.
• W2329510256 hasLocation W23295102562 @default.
• W2329510256 hasOpenAccess W2329510256 @default.
• W2329510256 hasPrimaryLocation W23295102561 @default.
• W2329510256 hasRelatedWork W1585268103 @default.
• W2329510256 hasRelatedWork W2008391194 @default.
• W2329510256 hasRelatedWork W2127153258 @default.

• next