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• W2329524318 abstract "Bacterial regulatory RNAs require the chaperone protein Hfq to enable their pairing to mRNAs. Recent data showed that there is a hierarchy among sRNAs in the competition for access to Hfq, which could be important for the tuning of sRNA-dependent translation regulation. Here, seven structurally different sRNAs were compared using filter-based competition assays. Moreover, chimeric sRNA constructs were designed to identify structure elements important for competition performance. The data showed that besides the 3′-terminal oligouridine sequences also the 5′-terminal structure elements of sRNAs were essential for their competition performance. When the binding of sRNAs to Hfq mutants was compared, the data showed the important role of the proximal and rim sites of Hfq for the binding of six out of seven sRNAs. However, ChiX sRNA, which was the most efficient competitor, bound Hfq in a unique way using the opposite—distal and proximal—faces of this ring-shaped protein. The data indicated that the simultaneous binding to the opposite faces of Hfq was enabled by separate adenosine-rich and uridine-rich sequences in the long, single-stranded region of ChiX. Overall, the results suggest that the individual structural composition of sRNAs serves to tune their performance to different levels resulting in a hierarchy of sRNAs in the competition for access to the Hfq protein." @default.
• W2329524318 created "2016-06-24" @default.
• W2329524318 creator A5001546999 @default.
• W2329524318 creator A5003186937 @default.
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• W2329524318 date "2015-01-26" @default.
• W2329524318 modified "2023-09-26" @default.
• W2329524318 title "Structure of Bacterial Regulatory RNAs Determines Their Performance in Competition for the Chaperone Protein Hfq" @default.
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• W2329524318 doi "https://doi.org/10.1021/bi500741d" @default.
• W2329524318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25582129" @default.
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