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• W2329559969 abstract "Phage display is a powerful technology that enables the discovery of peptide ligands for many targets. Chemical modification of phage libraries have allowed the identification of ligands with properties not encountered in natural polypeptides. In this report, we demonstrated the synthesis of 2 × 10(8) genetically encoded glycopeptides from a commercially available phage-displayed peptide library (Ph.D.-7) in a two-step, one-pot reaction in <1.5 h. Unlike previous reports, we bypassed genetic engineering of phage. The glycan moiety was introduced via an oxime ligation following oxidation of an N-terminal Ser/Thr; these residues are present in the peptide libraries at 20-30% abundance. The construction of libraries was facilitated by simple characterization, which directly assessed the yield and regioselectivity of chemical reactions performed on phage. This quantification method also allowed facile yield determination of reactions in 10(9) distinct molecules. We envision that the methodology described herein will find broad application in the synthesis of custom chemically modified phage libraries." @default.
• W2329559969 created "2016-06-24" @default.
• W2329559969 creator A5052087526 @default.
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• W2329559969 date "2012-07-10" @default.
• W2329559969 modified "2023-10-18" @default.
• W2329559969 title "Quantitative Synthesis of Genetically Encoded Glycopeptide Libraries Displayed on M13 Phage" @default.
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• W2329559969 doi "https://doi.org/10.1021/cb300187t" @default.
• W2329559969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22725642" @default.
• W2329559969 hasPublicationYear "2012" @default.
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