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- W2329561709 abstract "Owren described a patient who had a bleeding tendency due to the lack of clotting factor, namely, Factor V or labile factor in 1947. More than 70 patients with Factor V deficiency have been reported in foreign counties, while 29 cases have been described in Japan until present. A few cases of infants have been appeared in literatures.Prophylactic substituted treatment by use of fresh plasma or fresh frozen plasma during surgical operation and postoperative period has not been well documented in patients with Factor V deficiency. In most cases, transfusion therapy has been largely empirical.We present here a patient with congenital Factor V deficiency who has required an operation of eye ball extraction at the age of 9 months. The level of Factor V in our patient was less than 1.5% of normal control, whereas the concentration of other clotting factors were normal. Twelve hours before operation, 50ml of fresh plasma was infused intravenously. During the operation, 190ml of fresh frozen plasma was again infused and subsequently 50ml of same plasma has been given every 12 hours on the first to 7th day after the operation. During the operation and postoperative days, the Factors V level in his plasma was varied in the range of 10 to 63% of normal control value. No complications such as disturbance of healing proceses at the operated wound or severe hemorrhage have been noted throughout the whole postoperative course clinically, the patient appeared to have normal hemostasis.The half disappearance time of Factor V was 3 hours, determind by graphical results." @default.
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- W2329561709 date "1976-01-01" @default.
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- W2329561709 title "The use of fresh frozen plasma infusion in a patient with congenital factor V deficiency in a case of eye ball extraction" @default.
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- W2329561709 doi "https://doi.org/10.2491/jjsth1970.7.400" @default.
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