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- W2329620231 abstract "Abstract Background: The anti-cardiolipin and β 2 -glycoprotein I antibodies represent the important diagnostic parameters in routine autoimmune screening and represent the important diagnostic criteria for systemic lupus erythematosus (SLE). In this study, five different automated, semiautomated, and manual immunoassays detecting IgG/IgM anti-cardiolipin and anti-β 2 -glycoprotein I antibodies were tested. Methods: A total of 43 samples from the patients with SLE diagnosed in the rheumatology outpatient centers in Germany were included in this study. Results : For anticardiolipin and anti-β 2 -glycoprotein I, considerable differences in the percentage of the positive results were found between all the five methods, and the itemization of all the positive test results reached only a poor accordance. These findings were confirmed by Cohen’s κ coefficients. Conclusions: We found a moderate to poor accordance between the five different modern test systems for anticardiolipin and anti-β 2 -glycoprotein I antibodies. Such discrepancies can result in the clinical misinterpretation of data and may lead to wrong diagnoses. Therefore, further standardization of the tests for the antiphospholipid antibodies (APAs) is required." @default.
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- W2329620231 date "2013-05-09" @default.
- W2329620231 modified "2023-09-27" @default.
- W2329620231 title "Comparison of modern analyzers for the detection of antiphospholipid antibodies in patients with SLE" @default.
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- W2329620231 doi "https://doi.org/10.1515/labmed-2012-0076" @default.
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