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- W2329623118 abstract "Abasic sites are probably the most common lesions in DNA resulting from the hydrolytic cleavage of glycosidic bonds that can occur spontaneously and through DNA alkylation by anticancer agents, by radiotherapy, and during the repair processes of damaged nucleic bases. If not repaired, the abasic site can be mutagenic or lethal. Thus, compounds able to specifically bind and react at abasic sites have attracted much attention for therapeutic and diagnostic purposes. Here, we report on the efficient cleavage activity of characteristic antibiotic drugs of the major aminoglycosides (AG) family at abasic sites introduced either by depurination in a plasmidic DNA or site specifically in a synthetic oligonucleotide. Among the antibiotic AG drugs selected for this study, neomycin B is the most efficient (a 0.1 μM concentration induces 50% cleavage of an abasic site containing DNA). This cleavage activity could be related to aminoglycoside toxicity but also find medicinal applications through potentiation of cancer radiotherapy and chemotherapy with alkylating drugs. In the search for antibiotic and antiviral agents, we have previously described the synthesis of derivatives of the small aminoglycoside neamine, which corresponds to rings I and II of neomycin B constituted of four rings. The cleavage activity at abasic sites of four of these neamine derivatives is also reported in the present study. One of them appeared to be much more active than the parent compound neamine with cleavage efficiency close to that of neomycin." @default.
- W2329623118 created "2016-06-24" @default.
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- W2329623118 creator A5050606073 @default.
- W2329623118 creator A5059471038 @default.
- W2329623118 date "2013-10-30" @default.
- W2329623118 modified "2023-10-12" @default.
- W2329623118 title "Antibiotic Drugs Aminoglycosides Cleave DNA at Abasic Sites: Shedding New Light on Their Toxicity?" @default.
- W2329623118 cites W104409014 @default.
- W2329623118 cites W1548261300 @default.
- W2329623118 cites W1554627281 @default.
- W2329623118 cites W1968682237 @default.
- W2329623118 cites W1972838863 @default.
- W2329623118 cites W1975510750 @default.
- W2329623118 cites W1975532763 @default.
- W2329623118 cites W1977672038 @default.
- W2329623118 cites W1983544635 @default.
- W2329623118 cites W1985743923 @default.
- W2329623118 cites W1991114544 @default.
- W2329623118 cites W1991387321 @default.
- W2329623118 cites W1993418869 @default.
- W2329623118 cites W2001531321 @default.
- W2329623118 cites W2001688865 @default.
- W2329623118 cites W2007058577 @default.
- W2329623118 cites W2011487506 @default.
- W2329623118 cites W2011853845 @default.
- W2329623118 cites W2012514866 @default.
- W2329623118 cites W2018429609 @default.
- W2329623118 cites W2019288491 @default.
- W2329623118 cites W2020734526 @default.
- W2329623118 cites W2021876107 @default.
- W2329623118 cites W2023638011 @default.
- W2329623118 cites W2023706424 @default.
- W2329623118 cites W2024017407 @default.
- W2329623118 cites W2026414367 @default.
- W2329623118 cites W2027068536 @default.
- W2329623118 cites W2027340857 @default.
- W2329623118 cites W2028214064 @default.
- W2329623118 cites W2032833465 @default.
- W2329623118 cites W2036238712 @default.
- W2329623118 cites W2042660284 @default.
- W2329623118 cites W2044490287 @default.
- W2329623118 cites W2046343573 @default.
- W2329623118 cites W2046744660 @default.
- W2329623118 cites W2048172130 @default.
- W2329623118 cites W2049191611 @default.
- W2329623118 cites W2050671522 @default.
- W2329623118 cites W2053030041 @default.
- W2329623118 cites W2054233225 @default.
- W2329623118 cites W2054993235 @default.
- W2329623118 cites W2058292707 @default.
- W2329623118 cites W2066584600 @default.
- W2329623118 cites W2068351024 @default.
- W2329623118 cites W2069168271 @default.
- W2329623118 cites W2069289373 @default.
- W2329623118 cites W2072251062 @default.
- W2329623118 cites W2073359942 @default.
- W2329623118 cites W2074395670 @default.
- W2329623118 cites W2074997943 @default.
- W2329623118 cites W2075421260 @default.
- W2329623118 cites W2080912896 @default.
- W2329623118 cites W2083734806 @default.
- W2329623118 cites W2084621642 @default.
- W2329623118 cites W2084695608 @default.
- W2329623118 cites W2086223988 @default.
- W2329623118 cites W2089189535 @default.
- W2329623118 cites W2090749703 @default.
- W2329623118 cites W2093649670 @default.
- W2329623118 cites W2097432692 @default.
- W2329623118 cites W2101250552 @default.
- W2329623118 cites W2108377239 @default.
- W2329623118 cites W2108530765 @default.
- W2329623118 cites W2109522537 @default.
- W2329623118 cites W2111678587 @default.
- W2329623118 cites W2116214229 @default.
- W2329623118 cites W2126185450 @default.
- W2329623118 cites W2129775801 @default.
- W2329623118 cites W2129910477 @default.
- W2329623118 cites W2136439810 @default.
- W2329623118 cites W2146819733 @default.
- W2329623118 cites W2151485460 @default.
- W2329623118 cites W2158010208 @default.
- W2329623118 cites W2158426675 @default.
- W2329623118 cites W2170564800 @default.
- W2329623118 cites W2171867767 @default.
- W2329623118 cites W2949898612 @default.
- W2329623118 cites W4211018016 @default.
- W2329623118 cites W4211254771 @default.
- W2329623118 cites W4251633141 @default.
- W2329623118 cites W627224643 @default.
- W2329623118 cites W1997108226 @default.
- W2329623118 doi "https://doi.org/10.1021/tx4002836" @default.
- W2329623118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24127848" @default.
- W2329623118 hasPublicationYear "2013" @default.
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