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- W2329695000 abstract "<h3>Background</h3> Motor disturbances in Huntington9s disease can be subdivided into a predominantly choreatic or hypokinetic-rigid subtype. The relation between these motor subtypes and cognitive and general functioning is poorly understood, but can be of importance in the care for Huntington9s disease patients. <h3>Aims</h3> Investigating the possible clinical differences between predominantly choreatic and predominantly hypokinetic-rigid Huntington9s disease. <h3>Methods/technique</h3> Cross-sectional data from the European Huntington9s Disease Network Registry study up until 2011 were analysed. Data of the first visit of all subjects with an expanded CAG ≥36 and a total motor score ≥5 and complete cognitive, function and motor assessments were retrieved. A total of 1882 subjects were classified as predominantly choreatic (N=528) or predominantly hypokinetic-rigid (N=432), according to their score on those items of the total motor score a priori labelled as either choreatic or hypokinetic-rigid items; the other 922 patients were of a mixed motor type. The relationship between motor type and cognitive (total cognitive score) and general functioning (total functional capacity) was investigated using a linear regression model. <h3>Results/outcome</h3> Motor subtype was a significant predictor of both cognitive and general functioning (p<0.001). In both analyses the patients with the choreatic type had significantly better scores than those with the hypokinetic-rigid type. The total amount of variance explained by the cognitive model is 58% and by the general functioning model 56% (p<0.001). In both models motor subtype was the second most influential predictor (p<0.05). <h3>Conclusions</h3> We conclude that Huntington9s disease patients with a predominant choreatic motor phenotype exhibit better global and cognitive functioning than patients with a predominant hypokinetic-rigid motor phenotype." @default.
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- W2329695000 date "2012-08-29" @default.
- W2329695000 modified "2023-10-03" @default.
- W2329695000 title "A06 Better global and cognitive functioning for choreatic compared to hypokinetic-rigid huntington's disease" @default.
- W2329695000 doi "https://doi.org/10.1136/jnnp-2012-303524.6" @default.
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