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- W2329698907 abstract "Maintenance of the transparency and regular shape of the cornea are essential to the normal vision, whereas opacification of the tissue impairs vision. Fibrogenic reaction leading to scarring in an injured cornea is characterized by appearance of myofibroblasts, the key player of the fibrogenic reaction, and excess accumulation of fibrous extracellular matrix. Inflammatory/fibrogenic growth factors/cytokines produced by inflammatory cells play a pivotal role in fibrogenic response. Signaling systems involved in myofibroblast formation and fibrogenesis are activated by various growth factors, i.e., transforming growth factor β or others. Modulation of transforming growth factor β signal transduction molecules, e.g., Smad and mitogen-activated protein kinases, by gene transfer and other technology provides a new concept of prevention/treatment of unfavorable fibrogenesis in the cornea." @default.
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- W2329698907 date "2010-09-01" @default.
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- W2329698907 title "Transforming Growth Factor β Signal Transduction: A Potential Target for Maintenance/Restoration of Transparency of the Cornea" @default.
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- W2329698907 doi "https://doi.org/10.1097/icl.0b013e3181eef01c" @default.
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