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• W2329702948 abstract "Leptin is associated with the maintenance of epidermal growth factor (EGF)-reactive neural lineage cells, including the neural progenitors. One-day treatment with leptin (10, 100, or 1000 ng/ml) followed by EGF treatment increased the number of small-sized and mid-sized colonies compared with the nonleptin treatment. Leptin prevented the inactivation of the phosphatidylinositol 3-kinase (PI3 K) and extracellular signal regulated kinase (ERK) pathways in neurosphere cells cultured in the non-EGF medium. Bromodeoxyuridine (BrdU) incorporation into the neurosphere cells induced by leptin was suppressed by LY294002, a PI3 K inhibitor, but not by U0126, a MEK1/2 inhibitor, which activates ERK1/2, although U0126 decreased phosphorylated extracellular signal regulated kinase levels. These results suggest that leptin maintains the self-renewal ability and EGF reactivity of immature neural lineage cells and the signal is mediated, at least in part, by the PI3 K pathway." @default.
• W2329702948 created "2016-06-24" @default.
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• W2329702948 date "2010-12-29" @default.
• W2329702948 modified "2023-10-02" @default.
• W2329702948 title "Leptin and its intracellular signaling pathway maintains the neurosphere" @default.
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• W2329702948 doi "https://doi.org/10.1097/wnr.0b013e328340a74d" @default.
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