FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2329751012> ?p ?o ?g. }

• W2329751012 endingPage "3580" @default.
• W2329751012 startingPage "3567" @default.
• W2329751012 abstract "Nonfouling polymer architectures are considered important to the successful implementation of many biomaterials. It is thought that how these polymers induce conformational changes in proteins upon adsorption may dictate the fate of the device being utilized. Herein, oxidized silicon nanoparticles (SiNP) were modified with various forms of poly(carboxybetaine methacrylamide) (PCBMA) for the express purpose of understanding how polymer chemistry affects film hydration, adsorbed protein conformation, and clot formation kinetics. To this end, carboxybetaine monomers differing in intercharge separating spacer groups were synthesized, and nitroxide-mediated free radical polymerization (NMP) was conducted using alkoxyamine initiators with hydrophobic (TEMPO) and hydrophilic (β-phosphonate) terminal groups. The physical properties (surface composition, thickness, grafting density, etc.) of the resulting polymer-SiNP conjugates were quantified using several techniques, including Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), and thermogravimetric analysis (TGA). The effect of spacer group on the surface charge density was determined using zeta potential measurements. Three proteins, viz., lysozyme, bovine α-lactalbumin, and human serum albumin, were used to evaluate the effect film properties (charge, hydration, end-group) have on adsorbed protein conformation, as determined by circular dichroism (CD), fluorescence spectroscopy, and fluorescence quenching techniques. Hemocompatibility of these surfaces was observed by measuring clot formation kinetics using the plasma recalcification time assay. It was found that chain chemistry, as opposed to end-group chemistry, was a major determiner for water structure, adsorbed protein conformation, and clotting kinetics. It is thought that the systematic evaluation of how both chain (internal) and end-group (external) polymer properties affect film hydration, protein conformation, and clot formation will provide valuable insight that can be applied to all engineered surfaces for biomedical applications." @default.
• W2329751012 created "2016-06-24" @default.
• W2329751012 creator A5009043218 @default.
• W2329751012 creator A5013792701 @default.
• W2329751012 creator A5090226722 @default.
• W2329751012 date "2011-09-14" @default.
• W2329751012 modified "2023-09-28" @default.
• W2329751012 title "Poly(carboxybetaine methacrylamide)-Modified Nanoparticles: A Model System for Studying the Effect of Chain Chemistry on Film Properties, Adsorbed Protein Conformation, and Clot Formation Kinetics" @default.
• W2329751012 cites W1966785478 @default.
• W2329751012 cites W1966861054 @default.
• W2329751012 cites W1969388941 @default.
• W2329751012 cites W1969814828 @default.
• W2329751012 cites W1971237107 @default.
• W2329751012 cites W1974780522 @default.
• W2329751012 cites W1976685837 @default.
• W2329751012 cites W1980084976 @default.
• W2329751012 cites W1982192986 @default.
• W2329751012 cites W1982769493 @default.
• W2329751012 cites W1986577399 @default.
• W2329751012 cites W1986690534 @default.
• W2329751012 cites W1988824660 @default.
• W2329751012 cites W1994930875 @default.
• W2329751012 cites W1995690804 @default.
• W2329751012 cites W1995725157 @default.
• W2329751012 cites W1997465290 @default.
• W2329751012 cites W1997930025 @default.
• W2329751012 cites W1999404445 @default.
• W2329751012 cites W2002495991 @default.
• W2329751012 cites W2002691071 @default.
• W2329751012 cites W2007084683 @default.
• W2329751012 cites W2008215555 @default.
• W2329751012 cites W2010569689 @default.
• W2329751012 cites W2010738098 @default.
• W2329751012 cites W2011704533 @default.
• W2329751012 cites W2012144924 @default.
• W2329751012 cites W2012817964 @default.
• W2329751012 cites W2013718333 @default.
• W2329751012 cites W2013766835 @default.
• W2329751012 cites W2014369068 @default.
• W2329751012 cites W2020162388 @default.
• W2329751012 cites W2021354575 @default.
• W2329751012 cites W2021623392 @default.
• W2329751012 cites W2022535023 @default.
• W2329751012 cites W2023960255 @default.
• W2329751012 cites W2025059154 @default.
• W2329751012 cites W2025404727 @default.
• W2329751012 cites W2026727321 @default.
• W2329751012 cites W2032187323 @default.
• W2329751012 cites W2033495633 @default.
• W2329751012 cites W2033664949 @default.
• W2329751012 cites W2037810763 @default.
• W2329751012 cites W2046072382 @default.
• W2329751012 cites W2047119589 @default.
• W2329751012 cites W2051489942 @default.
• W2329751012 cites W2052426782 @default.
• W2329751012 cites W2056505651 @default.
• W2329751012 cites W2059702407 @default.
• W2329751012 cites W2059849792 @default.
• W2329751012 cites W2062832237 @default.
• W2329751012 cites W2063079745 @default.
• W2329751012 cites W2063468342 @default.
• W2329751012 cites W2065154471 @default.
• W2329751012 cites W2065435444 @default.
• W2329751012 cites W2065464185 @default.
• W2329751012 cites W2069658765 @default.
• W2329751012 cites W2071758457 @default.
• W2329751012 cites W2074880818 @default.
• W2329751012 cites W2075384227 @default.
• W2329751012 cites W2076469652 @default.
• W2329751012 cites W2076632124 @default.
• W2329751012 cites W2081808910 @default.
• W2329751012 cites W2082370264 @default.
• W2329751012 cites W2085561902 @default.
• W2329751012 cites W2087909895 @default.
• W2329751012 cites W2092125088 @default.
• W2329751012 cites W2095115698 @default.
• W2329751012 cites W2106878780 @default.
• W2329751012 cites W2113679220 @default.
• W2329751012 cites W2131789176 @default.
• W2329751012 cites W2136365726 @default.
• W2329751012 cites W2140260269 @default.
• W2329751012 cites W2152335094 @default.
• W2329751012 cites W2160471784 @default.
• W2329751012 cites W2395526635 @default.
• W2329751012 cites W2491458126 @default.
• W2329751012 cites W3104918095 @default.
• W2329751012 cites W4230354809 @default.
• W2329751012 cites W4234236777 @default.
• W2329751012 cites W4245480143 @default.
• W2329751012 doi "https://doi.org/10.1021/bm200778u" @default.
• W2329751012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21892823" @default.
• W2329751012 hasPublicationYear "2011" @default.
• W2329751012 type Work @default.
• W2329751012 sameAs 2329751012 @default.
• W2329751012 citedByCount "52" @default.
• W2329751012 countsByYear W23297510122012 @default.
• W2329751012 countsByYear W23297510122013 @default.
• W2329751012 countsByYear W23297510122014 @default.

• next