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- W2329856717 abstract "This work aimed to evaluate the effect of Diphenyl Dimethyl Bicarboxylate (DDB) or dexamethasone either alone or combined with praziquantel (PZQ) on different parasitological, immunological, and pathological parameters that reflect disease severity and morbidity in murine schistosomiasis. Diphenyl Dimethyl Bicarboxylate (DDB) or dexamethasone had no effect on worm burden but altered tissue egg distribution. This indicates that under the schedule used, both drugs did not interfere with the development of adult worms or oviposition but it can modulate liver pathology. Meanwhile, dexamethsone showed a marked reduction of granuloma size more than DDB. Dexamethasone-treated mice, also, showed lower levels of serum gamma interferon (IFN-γ), interleukin-12 (IL-12), and IL-4 together with higher IL-10 level compared to infected untreated control animals. These data suggested that dexamethasone is a convenient and promising co adjuvant agent causing decreased morbidity in murine schistosomiasis. (Journal of American Science 2010;6(4):138-145). (ISSN: 1545-1003)." @default.
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- W2329856717 date "2010-01-01" @default.
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- W2329856717 title "The effect of Diphenyl Dimethyl Bicarboxylate and Dexamethasone on Immunological and parasitological parameters in murine Schistosomiasis mansoni" @default.
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