Matches in SemOpenAlex for { <https://semopenalex.org/work/W2329884821> ?p ?o ?g. }
- W2329884821 endingPage "6898" @default.
- W2329884821 startingPage "6889" @default.
- W2329884821 abstract "[(μ4-η2)-(Prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS), a derivative of aspirin (ASS), demonstrated high growth-inhibitory potential against various tumor cells with interference in the arachidonic acid cascade as probable mode of action. The significance of the kind of metal and cluster was verified in this structure−activity study: Co2(CO)6 was respectively exchanged by a tetrameric cobalt-, trimeric ruthenium-, or trimeric ironcarbonyl cluster. Furthermore, the metal binding motif was changed from alkyne to 1,3-butadiene. Compounds were evaluated for growth inhibition, antiproliferative effects, and apoptosis induction in breast (MCF-7, MDA-MB 231) and colon cancer (HT-29) cell lines and for COX-1/2 inhibitory effects at isolated isoenzymes. Additionally, the major COX metabolite prostaglandin E2 (PGE2) was quantified in arachidonic acid-stimulated MDA-MB 231 breast tumor cells. It was demonstrated that the metal cluster was of minor importance for effects on cellular activity if an alkyne was used as ligand. Generally, no correlation existed between growth inhibition and COX activity. Cellular growth inhibition and antiproliferative activity at higher concentrations of the most active compounds Prop-ASS-Co4 and Prop-ASS-Ru3 correlated well with apoptosis induction." @default.
- W2329884821 created "2016-06-24" @default.
- W2329884821 creator A5004984536 @default.
- W2329884821 creator A5010963358 @default.
- W2329884821 creator A5050914535 @default.
- W2329884821 creator A5052486824 @default.
- W2329884821 creator A5057876555 @default.
- W2329884821 creator A5068338253 @default.
- W2329884821 creator A5083742458 @default.
- W2329884821 date "2010-09-21" @default.
- W2329884821 modified "2023-10-12" @default.
- W2329884821 title "Synthesis and Biological Activities of Transition Metal Complexes Based on Acetylsalicylic Acid as Neo-Anticancer Agents" @default.
- W2329884821 cites W1533624632 @default.
- W2329884821 cites W1907795058 @default.
- W2329884821 cites W1965261508 @default.
- W2329884821 cites W1977587295 @default.
- W2329884821 cites W1979621373 @default.
- W2329884821 cites W1994423788 @default.
- W2329884821 cites W1998612152 @default.
- W2329884821 cites W2008617419 @default.
- W2329884821 cites W2032018526 @default.
- W2329884821 cites W2035672855 @default.
- W2329884821 cites W2038482996 @default.
- W2329884821 cites W2038706001 @default.
- W2329884821 cites W2039914623 @default.
- W2329884821 cites W2041778777 @default.
- W2329884821 cites W2042087845 @default.
- W2329884821 cites W2044311286 @default.
- W2329884821 cites W2048727277 @default.
- W2329884821 cites W2050693842 @default.
- W2329884821 cites W2052736304 @default.
- W2329884821 cites W2053331531 @default.
- W2329884821 cites W2059046777 @default.
- W2329884821 cites W2085388752 @default.
- W2329884821 cites W2091356364 @default.
- W2329884821 cites W2092807969 @default.
- W2329884821 cites W2093725637 @default.
- W2329884821 cites W2131536047 @default.
- W2329884821 cites W2131787388 @default.
- W2329884821 cites W2133497268 @default.
- W2329884821 cites W2150335900 @default.
- W2329884821 cites W2152900998 @default.
- W2329884821 cites W2166882309 @default.
- W2329884821 cites W2170355137 @default.
- W2329884821 cites W2317724700 @default.
- W2329884821 cites W2321401325 @default.
- W2329884821 cites W2949424557 @default.
- W2329884821 cites W4251703036 @default.
- W2329884821 doi "https://doi.org/10.1021/jm101019j" @default.
- W2329884821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20857911" @default.
- W2329884821 hasPublicationYear "2010" @default.
- W2329884821 type Work @default.
- W2329884821 sameAs 2329884821 @default.
- W2329884821 citedByCount "45" @default.
- W2329884821 countsByYear W23298848212012 @default.
- W2329884821 countsByYear W23298848212013 @default.
- W2329884821 countsByYear W23298848212014 @default.
- W2329884821 countsByYear W23298848212015 @default.
- W2329884821 countsByYear W23298848212016 @default.
- W2329884821 countsByYear W23298848212017 @default.
- W2329884821 countsByYear W23298848212018 @default.
- W2329884821 countsByYear W23298848212019 @default.
- W2329884821 countsByYear W23298848212020 @default.
- W2329884821 countsByYear W23298848212021 @default.
- W2329884821 countsByYear W23298848212023 @default.
- W2329884821 crossrefType "journal-article" @default.
- W2329884821 hasAuthorship W2329884821A5004984536 @default.
- W2329884821 hasAuthorship W2329884821A5010963358 @default.
- W2329884821 hasAuthorship W2329884821A5050914535 @default.
- W2329884821 hasAuthorship W2329884821A5052486824 @default.
- W2329884821 hasAuthorship W2329884821A5057876555 @default.
- W2329884821 hasAuthorship W2329884821A5068338253 @default.
- W2329884821 hasAuthorship W2329884821A5083742458 @default.
- W2329884821 hasConcept C109316439 @default.
- W2329884821 hasConcept C116073593 @default.
- W2329884821 hasConcept C161790260 @default.
- W2329884821 hasConcept C181199279 @default.
- W2329884821 hasConcept C185592680 @default.
- W2329884821 hasConcept C190283241 @default.
- W2329884821 hasConcept C193042331 @default.
- W2329884821 hasConcept C202751555 @default.
- W2329884821 hasConcept C2778078955 @default.
- W2329884821 hasConcept C2779707156 @default.
- W2329884821 hasConcept C55493867 @default.
- W2329884821 hasConcept C555196967 @default.
- W2329884821 hasConcept C62112901 @default.
- W2329884821 hasConcept C71240020 @default.
- W2329884821 hasConceptScore W2329884821C109316439 @default.
- W2329884821 hasConceptScore W2329884821C116073593 @default.
- W2329884821 hasConceptScore W2329884821C161790260 @default.
- W2329884821 hasConceptScore W2329884821C181199279 @default.
- W2329884821 hasConceptScore W2329884821C185592680 @default.
- W2329884821 hasConceptScore W2329884821C190283241 @default.
- W2329884821 hasConceptScore W2329884821C193042331 @default.
- W2329884821 hasConceptScore W2329884821C202751555 @default.
- W2329884821 hasConceptScore W2329884821C2778078955 @default.
- W2329884821 hasConceptScore W2329884821C2779707156 @default.
- W2329884821 hasConceptScore W2329884821C55493867 @default.