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• W2329897002 endingPage "1915" @default.
• W2329897002 startingPage "1908" @default.
• W2329897002 abstract "Five new compounds, 16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid (1), 4,23,29-trihydroxy-3,4-seco-olean-12-en-3-oate-28-oic acid (2), 3β,6β,23-trihydroxyolean-12-en-28-oic acid 28-O-β-D-glucopyranoside (3), 3-O-[2,3-di-O-acetyl-α-L-arabinopyranosyl]hederagenin 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (4), and 3-O-[3,4-di-O-acetyl-α-L-arabinopyranosyl]hederagenin 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (5), as well as 10 known compounds (6-15), were isolated from the stem bark of Kalopanax pictus. Compounds 1-5 and 7-14 inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells in a dose-dependent manner, with IC50 values ranging from 0.6 to 16.4 μM. Furthermore, the transcriptional inhibitory function of these compounds was confirmed on the basis of decreases in COX-2 and iNOS gene expression in HepG2 cells. The structure-activity relationship of the compounds with respect to anti-inflammatory activity is also discussed." @default.
• W2329897002 created "2016-06-24" @default.
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• W2329897002 date "2011-08-26" @default.
• W2329897002 modified "2023-10-17" @default.
• W2329897002 title "Anti-inflammatory Triterpenoid Saponins from the Stem Bark of <i>Kalopanax pictus</i>" @default.
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• W2329897002 doi "https://doi.org/10.1021/np200382s" @default.
• W2329897002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21870831" @default.
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