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- W2329908842 abstract "THE TWO BINDING SITES of most antibodies can bind only one type of antigen. However, Genentech researchers have now designed a “two-in-one” antibody that reshapes its binding sites to recognize and tightly bind two completely different antigens ( Science 2009, 323 , 1610). This ability could be extended to other antibodies and antigens and could lead to improved dual-target therapies for cancers and autoimmune diseases. A few other researchers have previously created antibody molecules with dual binding capabilities, according to a commentary about the work by Dennis R. Burton of Scripps Research Institute and Paul W.H.I. Parren of Genmab, a biotech firm in the Netherlands that focuses on antibody-based cancer treatments. But they write that the Genentech process is the first to engineer dual specificity “into a naturally occurring and stable antibody [type] that should pose no obstacles for manufacturing and that has been well validated for clinical use.” Genentech’s Germaine Fuh and colleagues created ..." @default.
- W2329908842 created "2016-06-24" @default.
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- W2329908842 date "2009-03-23" @default.
- W2329908842 modified "2023-09-25" @default.
- W2329908842 title "MODIFIED ANTIBODY BINDS TWO ANTIGENS" @default.
- W2329908842 doi "https://doi.org/10.1021/cen-v087n012.p010a" @default.
- W2329908842 hasPublicationYear "2009" @default.
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