Matches in SemOpenAlex for { <https://semopenalex.org/work/W2329921793> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2329921793 abstract "Objective: To investigate the sleep/wake and 24-hour periodicity of evolutions into generalized tonic-clonic seizures. Background Generalized tonic-clonic seizures may evolve from seizures of variable semiology. These seizures constitute a risk factor for accidents, status epilepticus and sudden unexpected death in epilepsy. Design/Methods: Charts of 407 consecutive patients with epilepsy aged 0-21 years undergoing continuous video-EEG monitoring were reviewed for the presence of evolution into generalized tonic-clonic seizures. Seizures were characterized according to 2001 ILAE terminology. Charts were reviewed for EEG localization, MRI lesions, and seizure timing in 3-hour time blocks, out of sleep or wakefulness, and during the day (6AM-6PM) or night. Analysis was done with binomial testing. Results: Seventy-one patients (32 girls, mean age 12.63±5.3 years) had 223 seizures with evolutions into tonic-clonic semiology. Sleep/wakefulness was more related to seizure evolution than time of day, with more evolutions during sleep (p Conclusions: Evolutions to generalized tonic-clonic seizures from focal epilepsy occur more frequently out of sleep and in the morning. These findings contribute to the pathophysiological understanding of seizures and towards individualized therapies, including differential dosing and light therapy. Disclosure: Dr. Ramgopal has nothing to disclose. Dr. Shah has nothing to disclose. Dr. Vendrame has nothing to disclose. Dr. Zarowski has nothing to disclose. Dr. Alexopoulos has received personal compensation for activities with UCB Pharma as a speaker. Dr. Wyllie has nothing to disclose. Dr. Kothare has nothing to disclose. Dr. Loddenkemper has received personal compensation for activities with Eisai Inc. as a consultant. Dr. Loddenkemper has received research support from NIH/NINDS, The Epilepsy Foundation of America, CIMIT/DOD, Harvard Medical School Office of Faculty Development, and the Children9s Hospital Program for Patient Safety and Quality Improvement." @default.
- W2329921793 created "2016-06-24" @default.
- W2329921793 creator A5004487091 @default.
- W2329921793 creator A5037328246 @default.
- W2329921793 creator A5046645524 @default.
- W2329921793 creator A5052755790 @default.
- W2329921793 creator A5056051023 @default.
- W2329921793 creator A5062982325 @default.
- W2329921793 creator A5066306563 @default.
- W2329921793 creator A5086600743 @default.
- W2329921793 date "2012-04-22" @default.
- W2329921793 modified "2023-09-23" @default.
- W2329921793 title "Diurnal and Sleep/Wake Patterns of Evolutions to Tonic-Clonic Seizures in Pediatric Epilepsy (P04.019)" @default.
- W2329921793 doi "https://doi.org/10.1212/wnl.78.1_meetingabstracts.p04.019" @default.
- W2329921793 hasPublicationYear "2012" @default.
- W2329921793 type Work @default.
- W2329921793 sameAs 2329921793 @default.
- W2329921793 citedByCount "0" @default.
- W2329921793 crossrefType "journal-article" @default.
- W2329921793 hasAuthorship W2329921793A5004487091 @default.
- W2329921793 hasAuthorship W2329921793A5037328246 @default.
- W2329921793 hasAuthorship W2329921793A5046645524 @default.
- W2329921793 hasAuthorship W2329921793A5052755790 @default.
- W2329921793 hasAuthorship W2329921793A5056051023 @default.
- W2329921793 hasAuthorship W2329921793A5062982325 @default.
- W2329921793 hasAuthorship W2329921793A5066306563 @default.
- W2329921793 hasAuthorship W2329921793A5086600743 @default.
- W2329921793 hasConcept C111472728 @default.
- W2329921793 hasConcept C118552586 @default.
- W2329921793 hasConcept C127573956 @default.
- W2329921793 hasConcept C136815107 @default.
- W2329921793 hasConcept C138885662 @default.
- W2329921793 hasConcept C15744967 @default.
- W2329921793 hasConcept C169760540 @default.
- W2329921793 hasConcept C2777341932 @default.
- W2329921793 hasConcept C2778186239 @default.
- W2329921793 hasConcept C2779320081 @default.
- W2329921793 hasConcept C42219234 @default.
- W2329921793 hasConcept C522805319 @default.
- W2329921793 hasConcept C71924100 @default.
- W2329921793 hasConceptScore W2329921793C111472728 @default.
- W2329921793 hasConceptScore W2329921793C118552586 @default.
- W2329921793 hasConceptScore W2329921793C127573956 @default.
- W2329921793 hasConceptScore W2329921793C136815107 @default.
- W2329921793 hasConceptScore W2329921793C138885662 @default.
- W2329921793 hasConceptScore W2329921793C15744967 @default.
- W2329921793 hasConceptScore W2329921793C169760540 @default.
- W2329921793 hasConceptScore W2329921793C2777341932 @default.
- W2329921793 hasConceptScore W2329921793C2778186239 @default.
- W2329921793 hasConceptScore W2329921793C2779320081 @default.
- W2329921793 hasConceptScore W2329921793C42219234 @default.
- W2329921793 hasConceptScore W2329921793C522805319 @default.
- W2329921793 hasConceptScore W2329921793C71924100 @default.
- W2329921793 hasLocation W23299217931 @default.
- W2329921793 hasOpenAccess W2329921793 @default.
- W2329921793 hasPrimaryLocation W23299217931 @default.
- W2329921793 hasRelatedWork W19879499 @default.
- W2329921793 hasRelatedWork W1988660505 @default.
- W2329921793 hasRelatedWork W1992806350 @default.
- W2329921793 hasRelatedWork W2011703489 @default.
- W2329921793 hasRelatedWork W2029680211 @default.
- W2329921793 hasRelatedWork W2044976974 @default.
- W2329921793 hasRelatedWork W2111805161 @default.
- W2329921793 hasRelatedWork W2147310984 @default.
- W2329921793 hasRelatedWork W2167309854 @default.
- W2329921793 hasRelatedWork W2274471345 @default.
- W2329921793 hasRelatedWork W2397039807 @default.
- W2329921793 hasRelatedWork W2732804856 @default.
- W2329921793 hasRelatedWork W2737361791 @default.
- W2329921793 hasRelatedWork W2746839482 @default.
- W2329921793 hasRelatedWork W2765781830 @default.
- W2329921793 hasRelatedWork W2901156790 @default.
- W2329921793 hasRelatedWork W2911827552 @default.
- W2329921793 hasRelatedWork W2914172860 @default.
- W2329921793 hasRelatedWork W2965722104 @default.
- W2329921793 hasRelatedWork W3081248472 @default.
- W2329921793 isParatext "false" @default.
- W2329921793 isRetracted "false" @default.
- W2329921793 magId "2329921793" @default.
- W2329921793 workType "article" @default.