Matches in SemOpenAlex for { <https://semopenalex.org/work/W2329943493> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2329943493 abstract "Hepatocyte transplantation is an alternative to whole liver transplantation. Yet, the cellular and molecular mechansims prompting integration are largely unknown. We previously reported that the poor liver repopulation efficacy by transplanted hepatocytes in adult recipient livers is probably due to the host microenviroment and caused by the inefficient regulation of the growth hormon-IGF1-axis. The aim of this study was to investigate the effects of growth hormone on liver repopulation by transplantated hepatocytes. The age-dependent proliferative potential of wild type F344 rat hepatocytes was investigated after transplantation and administration of recombinant human growth hormon (rhGH) into old CD26-deficient F344 rat host livers. Repopulation rates were verified by flow cytometry and assay of CD26 enzyme activity. Cell cycle-dependent protein expression of C/EBPalpha and PP2A was determined. Detection of serum levels of rhGH indicated the efficient increase after systemic administration before and during hepatocyte transplantation. Hepatocytes isolated from either young or old donor rats formed bigger clusters of donor-derived hepatocytes in senescent host livers treated with rhGH as compared to untreated livers. Repopulation of senescent host livers by old or young hepatocytes after treatment with rhGH was 10 times higher as compared to untreated hosts. No functional difference between transplanted juvenile and senescent hepatocytes was observed in the host liver tissue as assessed by glycogen storage. The protein expression of C/EBPalpha and PP2A revealed the recovery of the senescent host liver microenviroment after treatment with rhGH favouring growth of transplanted hepatocytes, derived from both young and old donors, in the recipient senescent liver. Thus, in rats, the age of the recipient liver and the regulation along the growth hormone-IGF1-axis impacts repopulation by transplanted hepatocytes." @default.
- W2329943493 created "2016-06-24" @default.
- W2329943493 creator A5017373103 @default.
- W2329943493 creator A5028621506 @default.
- W2329943493 creator A5048916978 @default.
- W2329943493 creator A5057394610 @default.
- W2329943493 creator A5063796458 @default.
- W2329943493 creator A5071284274 @default.
- W2329943493 date "2011-01-01" @default.
- W2329943493 modified "2023-09-27" @default.
- W2329943493 title "Short term treatment of old-aged recipient rats with growth hormone improves liver repopulation by transplanted hepatocytes" @default.
- W2329943493 doi "https://doi.org/10.1055/s-0030-1269645" @default.
- W2329943493 hasPublicationYear "2011" @default.
- W2329943493 type Work @default.
- W2329943493 sameAs 2329943493 @default.
- W2329943493 citedByCount "0" @default.
- W2329943493 crossrefType "journal-article" @default.
- W2329943493 hasAuthorship W2329943493A5017373103 @default.
- W2329943493 hasAuthorship W2329943493A5028621506 @default.
- W2329943493 hasAuthorship W2329943493A5048916978 @default.
- W2329943493 hasAuthorship W2329943493A5057394610 @default.
- W2329943493 hasAuthorship W2329943493A5063796458 @default.
- W2329943493 hasAuthorship W2329943493A5071284274 @default.
- W2329943493 hasConcept C109159458 @default.
- W2329943493 hasConcept C126322002 @default.
- W2329943493 hasConcept C134018914 @default.
- W2329943493 hasConcept C16685009 @default.
- W2329943493 hasConcept C195521686 @default.
- W2329943493 hasConcept C202751555 @default.
- W2329943493 hasConcept C2776200302 @default.
- W2329943493 hasConcept C2780918802 @default.
- W2329943493 hasConcept C28328180 @default.
- W2329943493 hasConcept C2908801736 @default.
- W2329943493 hasConcept C2911091166 @default.
- W2329943493 hasConcept C55493867 @default.
- W2329943493 hasConcept C71924100 @default.
- W2329943493 hasConcept C86803240 @default.
- W2329943493 hasConcept C95444343 @default.
- W2329943493 hasConceptScore W2329943493C109159458 @default.
- W2329943493 hasConceptScore W2329943493C126322002 @default.
- W2329943493 hasConceptScore W2329943493C134018914 @default.
- W2329943493 hasConceptScore W2329943493C16685009 @default.
- W2329943493 hasConceptScore W2329943493C195521686 @default.
- W2329943493 hasConceptScore W2329943493C202751555 @default.
- W2329943493 hasConceptScore W2329943493C2776200302 @default.
- W2329943493 hasConceptScore W2329943493C2780918802 @default.
- W2329943493 hasConceptScore W2329943493C28328180 @default.
- W2329943493 hasConceptScore W2329943493C2908801736 @default.
- W2329943493 hasConceptScore W2329943493C2911091166 @default.
- W2329943493 hasConceptScore W2329943493C55493867 @default.
- W2329943493 hasConceptScore W2329943493C71924100 @default.
- W2329943493 hasConceptScore W2329943493C86803240 @default.
- W2329943493 hasConceptScore W2329943493C95444343 @default.
- W2329943493 hasIssue "01" @default.
- W2329943493 hasLocation W23299434931 @default.
- W2329943493 hasOpenAccess W2329943493 @default.
- W2329943493 hasPrimaryLocation W23299434931 @default.
- W2329943493 hasRelatedWork W1855195526 @default.
- W2329943493 hasRelatedWork W1921357624 @default.
- W2329943493 hasRelatedWork W2044988659 @default.
- W2329943493 hasRelatedWork W2084505320 @default.
- W2329943493 hasRelatedWork W2088891312 @default.
- W2329943493 hasRelatedWork W2094423915 @default.
- W2329943493 hasRelatedWork W2133707772 @default.
- W2329943493 hasRelatedWork W2466450716 @default.
- W2329943493 hasRelatedWork W3157082172 @default.
- W2329943493 hasRelatedWork W2337002345 @default.
- W2329943493 hasVolume "49" @default.
- W2329943493 isParatext "false" @default.
- W2329943493 isRetracted "false" @default.
- W2329943493 magId "2329943493" @default.
- W2329943493 workType "article" @default.