Matches in SemOpenAlex for { <https://semopenalex.org/work/W2329948280> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2329948280 endingPage "S108" @default.
- W2329948280 startingPage "S108" @default.
- W2329948280 abstract "Irritable Bowel Syndrome (IBS), such as Crohn’s disease (CD), is an intestinal disease that is associated with colonic hypersensitivity and abdominal pain associated with other symptoms (bloating and bowel dysfunction). Moreover, alterations in innate immune function genes and activities have been described in IBS and CD patients. Among them, Toll-Like Receptor 5 (TLR5) is a primordial innate immune receptor, responsible for the primary defense of the organism against microbial intruders. This receptor acts as a sentinel by detecting the presence of potentially virulent invasive bacteria expressing flagellin, the microbial TLR5 ligand. Mice deficient in TLR5 (T5KO) have been described to uniformly exhibit increased levels of inflammatory markers, resulting in a “sub-clinical” inflammation. Consequently, we hypothesized that, depending on the level of intestinal inflammation, T5KO mice will spontaneously develop a visceral hypersensitivity and thus provide a practical means to study mechanisms underlying inflammation and visceral pain. Two distinct strains of T5KO mice (knockout mouse strains on the C57BL/6 background deficient in TLR5 from Drs. Akira and Flavell) were assayed for intestinal inflammation level and visceral hypersensitivity. Inflammation was monitored using clinical anatomical indicators of colitis such as spleen and colon weight, and assessed by determination of the colonic myeloperoxidase (MPO) activity and expression of systemic pro-inflammatory cytokines. In parallel, visceral hypersensitivity was assessed using a technique based on measuring electromyographic abdominal contractions induced by colorectal distension. This test is to induce, by progressive inflation of a balloon inserted into the colon, stomach cramps whose amplitude is proportional to the colon sensitivity. Mice deficient for TLR5 uniformly exhibited increased levels of inflammatory markers and greater visceral hypersensitivity in comparison to their housekeeping WT mice. Direct involvement of TLR5 in colonic hypersensitivity has been demonstrated. Such impact on colonic sensitivity could be related to its role in the modulation of the intestinal microbiota and its role on micro-colonic inflammations. Thus, approaches focused on TLR5-dependent pathway could be used to initiate new pharmacological strategies based on the use of specific molecules modulating the activity of this protein." @default.
- W2329948280 created "2016-06-24" @default.
- W2329948280 creator A5019350885 @default.
- W2329948280 creator A5024324108 @default.
- W2329948280 creator A5074874098 @default.
- W2329948280 creator A5075478051 @default.
- W2329948280 creator A5082419541 @default.
- W2329948280 creator A5087444618 @default.
- W2329948280 date "2012-12-01" @default.
- W2329948280 modified "2023-10-18" @default.
- W2329948280 title "Defect in TLR5 Expression Enhances Spontaneous Visceral Hypersensitivity" @default.
- W2329948280 doi "https://doi.org/10.1097/00054725-201212001-00276" @default.
- W2329948280 hasPublicationYear "2012" @default.
- W2329948280 type Work @default.
- W2329948280 sameAs 2329948280 @default.
- W2329948280 citedByCount "0" @default.
- W2329948280 crossrefType "journal-article" @default.
- W2329948280 hasAuthorship W2329948280A5019350885 @default.
- W2329948280 hasAuthorship W2329948280A5024324108 @default.
- W2329948280 hasAuthorship W2329948280A5074874098 @default.
- W2329948280 hasAuthorship W2329948280A5075478051 @default.
- W2329948280 hasAuthorship W2329948280A5082419541 @default.
- W2329948280 hasAuthorship W2329948280A5087444618 @default.
- W2329948280 hasBestOaLocation W23299482801 @default.
- W2329948280 hasConcept C126322002 @default.
- W2329948280 hasConcept C136449434 @default.
- W2329948280 hasConcept C15490471 @default.
- W2329948280 hasConcept C170493617 @default.
- W2329948280 hasConcept C203014093 @default.
- W2329948280 hasConcept C2775862500 @default.
- W2329948280 hasConcept C2776709828 @default.
- W2329948280 hasConcept C2776914184 @default.
- W2329948280 hasConcept C2777338127 @default.
- W2329948280 hasConcept C2778260677 @default.
- W2329948280 hasConcept C2778271842 @default.
- W2329948280 hasConcept C2779134260 @default.
- W2329948280 hasConcept C2779794527 @default.
- W2329948280 hasConcept C71924100 @default.
- W2329948280 hasConcept C8891405 @default.
- W2329948280 hasConceptScore W2329948280C126322002 @default.
- W2329948280 hasConceptScore W2329948280C136449434 @default.
- W2329948280 hasConceptScore W2329948280C15490471 @default.
- W2329948280 hasConceptScore W2329948280C170493617 @default.
- W2329948280 hasConceptScore W2329948280C203014093 @default.
- W2329948280 hasConceptScore W2329948280C2775862500 @default.
- W2329948280 hasConceptScore W2329948280C2776709828 @default.
- W2329948280 hasConceptScore W2329948280C2776914184 @default.
- W2329948280 hasConceptScore W2329948280C2777338127 @default.
- W2329948280 hasConceptScore W2329948280C2778260677 @default.
- W2329948280 hasConceptScore W2329948280C2778271842 @default.
- W2329948280 hasConceptScore W2329948280C2779134260 @default.
- W2329948280 hasConceptScore W2329948280C2779794527 @default.
- W2329948280 hasConceptScore W2329948280C71924100 @default.
- W2329948280 hasConceptScore W2329948280C8891405 @default.
- W2329948280 hasLocation W23299482801 @default.
- W2329948280 hasOpenAccess W2329948280 @default.
- W2329948280 hasPrimaryLocation W23299482801 @default.
- W2329948280 hasRelatedWork W1519633296 @default.
- W2329948280 hasRelatedWork W1931231627 @default.
- W2329948280 hasRelatedWork W1993150527 @default.
- W2329948280 hasRelatedWork W2084402420 @default.
- W2329948280 hasRelatedWork W2141330728 @default.
- W2329948280 hasRelatedWork W2141918445 @default.
- W2329948280 hasRelatedWork W2151289268 @default.
- W2329948280 hasRelatedWork W2280390285 @default.
- W2329948280 hasRelatedWork W2894287585 @default.
- W2329948280 hasRelatedWork W37086585 @default.
- W2329948280 hasVolume "18" @default.
- W2329948280 isParatext "false" @default.
- W2329948280 isRetracted "false" @default.
- W2329948280 magId "2329948280" @default.
- W2329948280 workType "article" @default.