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- W2329958641 abstract "Human acute myeloid leukemia cells overexpresses a beta–like DNA polymerase (EC 2.7.7.7) which is foundto be a chromatin associated single subunit protein (66.5 kDa) purified by original extraction/gel filtration procedureallowing to gain the 122,000-fold purification degree as corrected to a total cell protein. The enzyme possessessome key DNA pol β-specific catalytic properties such as the processing of short (200n-250n) single strand DNAsequences, activation in the presence of 200 mM KCl, resistance to N-ethyl-melamide and Aphidicolin, lack of3’,5’-exonuclease activity, and low dTTP utilization rates (KM=0.016 mM, Kcat=0.622 (μM dTTP/min)/mg protein). Apossible significance of the unique enzyme studied as a target for its pharmaceutical inhibitors is under discussion.This work is a full–length version of a study presented as a Poster at the OMICS managed 2nd World Congress onScience Cancer and Therapy, Sept 10–12, 2012, San Antonio, TX." @default.
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- W2329958641 date "2013-01-01" @default.
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- W2329958641 title "An Atypical DNA Polymerase Beta Overexpressed in Human Aml/Hl-60 Malignant Cells" @default.
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- W2329958641 doi "https://doi.org/10.4172/1948-5956.1000191" @default.
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