FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2329990346> ?p ?o ?g. }

• W2329990346 endingPage "547" @default.
• W2329990346 startingPage "539" @default.
• W2329990346 abstract "Comparative genomic hybridisation (CGH) represents an alternative molecular-cytogenetic technique capable of detecting chromosomal imbalances by reverse fluorescence in situ hybridisation. As the technique uses genomic DNA for assessment it does not rely on metaphase chromosomes in the test material and thus circumvents technical problems associated with tissue culturing. In the present study, we applied CGH to identify chromosome anomalies in 60 spontaneous abortions of the first trimester, that had failed to grow in culture. In 57 out of 60 cases CGH analyses were successful. The overall aneuploidy rate detected was 72%. Trisomy was the predominant chromosome anomaly accounting for 68.0% of abnormal abortions, followed by triploidy (17.1%) and monosomy X (9.8%). An unbalanced structural rearrangement was found in one (2.4%) abortion. Most frequently involved in trisomies were chromosomes 16 (32.1%), 7 and 22 (10.7% each), 4, 13, 15, and 21 (7.2 % each). Three triploid cases and one complete mole were detected by microsatellite analysis as supplementary method. CGH data on culture failures were compared with data derived from 4693 successfully karyotyped first trimester spontaneous abortions, resulting in a chromosome aberration rate of 64.8%. The distribution of the different chromosome anomalies was similar with the exception of a higher rate of trisomies 7 and of XYY-triploidies in the culture failures. Based on our data we suggest that the genetic contribution to pregnancy loss is still underestimated. Investigating abortion tissues hitherto unassessed by conventional methods, we suggest that the contribution of chromosome aberrations to first trimester pregnancy loss is nearly 70%." @default.
• W2329990346 created "2016-06-24" @default.
• W2329990346 creator A5021457538 @default.
• W2329990346 creator A5028416541 @default.
• W2329990346 creator A5032089746 @default.
• W2329990346 creator A5043700263 @default.
• W2329990346 creator A5046514948 @default.
• W2329990346 creator A5053674402 @default.
• W2329990346 creator A5065581407 @default.
• W2329990346 creator A5071120787 @default.
• W2329990346 creator A5072627619 @default.
• W2329990346 creator A5081577531 @default.
• W2329990346 date "2001-07-01" @default.
• W2329990346 modified "2023-10-11" @default.
• W2329990346 title "Cytogenetic analyses of culture failures by comparative genomic hybridisation (CGH)–Re-evaluation of chromosome aberration rates in early spontaneous abortions" @default.
• W2329990346 cites W134798232 @default.
• W2329990346 cites W1547611357 @default.
• W2329990346 cites W1627650798 @default.
• W2329990346 cites W1968046362 @default.
• W2329990346 cites W1968659359 @default.
• W2329990346 cites W1969762111 @default.
• W2329990346 cites W1982719543 @default.
• W2329990346 cites W1985060359 @default.
• W2329990346 cites W1991416384 @default.
• W2329990346 cites W1991469965 @default.
• W2329990346 cites W1999055424 @default.
• W2329990346 cites W2001445533 @default.
• W2329990346 cites W2005773599 @default.
• W2329990346 cites W2009808778 @default.
• W2329990346 cites W2017392622 @default.
• W2329990346 cites W2018037409 @default.
• W2329990346 cites W2021647091 @default.
• W2329990346 cites W2029448399 @default.
• W2329990346 cites W2029824662 @default.
• W2329990346 cites W2033845019 @default.
• W2329990346 cites W2037463717 @default.
• W2329990346 cites W2039350411 @default.
• W2329990346 cites W2040316588 @default.
• W2329990346 cites W2041561003 @default.
• W2329990346 cites W2046605880 @default.
• W2329990346 cites W2047027501 @default.
• W2329990346 cites W2058960872 @default.
• W2329990346 cites W2059627829 @default.
• W2329990346 cites W2060561167 @default.
• W2329990346 cites W2062201772 @default.
• W2329990346 cites W2066022135 @default.
• W2329990346 cites W2066420474 @default.
• W2329990346 cites W2066775772 @default.
• W2329990346 cites W2067811308 @default.
• W2329990346 cites W2068411454 @default.
• W2329990346 cites W2069591078 @default.
• W2329990346 cites W2083287129 @default.
• W2329990346 cites W2083495987 @default.
• W2329990346 cites W2085667759 @default.
• W2329990346 cites W2118094114 @default.
• W2329990346 cites W2127301911 @default.
• W2329990346 cites W2135164021 @default.
• W2329990346 cites W2145660338 @default.
• W2329990346 cites W2153811589 @default.
• W2329990346 cites W2168035946 @default.
• W2329990346 cites W2268619476 @default.
• W2329990346 doi "https://doi.org/10.1038/sj.ejhg.5200669" @default.
• W2329990346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11464246" @default.
• W2329990346 hasPublicationYear "2001" @default.
• W2329990346 type Work @default.
• W2329990346 sameAs 2329990346 @default.
• W2329990346 citedByCount "135" @default.
• W2329990346 countsByYear W23299903462012 @default.
• W2329990346 countsByYear W23299903462013 @default.
• W2329990346 countsByYear W23299903462014 @default.
• W2329990346 countsByYear W23299903462015 @default.
• W2329990346 countsByYear W23299903462016 @default.
• W2329990346 countsByYear W23299903462017 @default.
• W2329990346 countsByYear W23299903462018 @default.
• W2329990346 countsByYear W23299903462019 @default.
• W2329990346 countsByYear W23299903462020 @default.
• W2329990346 countsByYear W23299903462021 @default.
• W2329990346 countsByYear W23299903462022 @default.
• W2329990346 countsByYear W23299903462023 @default.
• W2329990346 crossrefType "journal-article" @default.
• W2329990346 hasAuthorship W2329990346A5021457538 @default.
• W2329990346 hasAuthorship W2329990346A5028416541 @default.
• W2329990346 hasAuthorship W2329990346A5032089746 @default.
• W2329990346 hasAuthorship W2329990346A5043700263 @default.
• W2329990346 hasAuthorship W2329990346A5046514948 @default.
• W2329990346 hasAuthorship W2329990346A5053674402 @default.
• W2329990346 hasAuthorship W2329990346A5065581407 @default.
• W2329990346 hasAuthorship W2329990346A5071120787 @default.
• W2329990346 hasAuthorship W2329990346A5072627619 @default.
• W2329990346 hasAuthorship W2329990346A5081577531 @default.
• W2329990346 hasBestOaLocation W23299903461 @default.
• W2329990346 hasConcept C104317684 @default.
• W2329990346 hasConcept C124942203 @default.
• W2329990346 hasConcept C131872663 @default.
• W2329990346 hasConcept C174475383 @default.
• W2329990346 hasConcept C2776229224 @default.
• W2329990346 hasConcept C2778642596 @default.
• W2329990346 hasConcept C2779142324 @default.

• next