FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330001346> ?p ?o ?g. }

• W2330001346 abstract "Event Abstract Back to Event Specific oligoclonal T-cell recruitment within epicardial adipose tissue of patients with acute coronary syndrome: evidence for a local, immune-mediated, pathogenetic mechanism Gabriele Di Sante1*, Giovanna Liuzzo2, Anna Severino2, Vincenzo Pazzano2, Daniela Pedicino2, Franco Glieca3, Luciani Nicola3, Francesco Ria1 and Filippo Crea2 1 Università Cattolica del Sacro Cuore - Policlinico Gemelli, General Pathology, Italy 2 Università Cattolica del Sacro Cuore, Cardiovascular Disease, Italy 3 Università Cattolica del Sacro Cuore, Cardiosurgery, Italy Epicardial adipose tissue (EAT) has a close functional and anatomic relationship with epicardial coronary arteries (1). Release of proinflammatory cytokines, associated with macrophage infiltration, have been demonstrated in EAT of patients with coronary artery disease (CAD), although without any distinction between chronic and acute manifestations of the disease. The present study aims to address whether a specific, immune-driven T-lymphocyte recruitment within EAT might be implicated in acute coronary syndrome (ACS) (1-3). We examined the T-cell receptor (TCR) repertoire using CDR3 BV-BC spectratyping (4-6) both in EAT samples (obtained during coronary artery bypass grafting) and in peripheral blood mononuclear cells of patients with either ACS (n=27) or CAD as chronic stable angina (n=26). Patients undergoing cardiac surgery for mitral insufficiency, with angiographically normal coronary arteries, served as control group (controls; n=10). We found T-cell clonotype expansions in EAT as compared with peripheral blood from each patient with ACS. The TCR repertoire in EAT samples of ACS patients was restricted, involving 6/21 (24%) analyzed TCR-BV families (BV3, BV6.2, BV7, BV9, BV10, BV12). In particular, we observed a disproportionately high expression of TCR-BV10 and BV6.2, as they were found in 12 (44%) and in 7 (26%) out of 27 EAT samples, respectively. Intriguingly, TCR-BV10 was strongly associated with the first clinical manifestation of ACS, as 11/18 (61%) patients at their first manifestation of ACS and 1/9 (11%) of those with previous acute coronary events expressed BV10 (P=0.019). Although the size of the repertoire used by CAD and control was comparable to that of ACS patients (7), it was characterized by different T-cell receptors. CAD patients expressed preferentially TCR-BV3 that was observed in 16/26 (62%) EAT samples, while BV10 and BV6.2 (both 8%) were less frequent (P<0.01 vs ACS). Controls expressed BV3 (30%) and BV9 (20%), but none had BV10 or BV6.2 (P<0.01 vs ACS). Thus, TCR-BV10 and BV6.2 usage was almost exclusively observed in patients at their first clinical manifestation of ACS, while TCR-BV3 was a prerogative of chronic CAD. For the first time, T-cell receptor repertoire was investigated directly into epicardial adipose tissue surrounding diseased coronary arteries. Using this approach, we demonstrated that coronary plaque instability in the setting of ACS is associated with immune-driven T-cell recruitment, not only within the plaque, but also in the surrounding adipose tissue, and that T-cells bearing selected TCRs might be involved in the pathogenesis of ACS. Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 References 1. Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, Sarov-Blat L, O'Brien S, Keiper EA, Johnson AG, Martin J, Goldstein BJ, Shi Y. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003 Nov 18;108(20):2460-6. Epub 2003 Oct 27. 2. Karastergiou K, Evans I, Ogston N, Miheisi N, Nair D, Kaski JC, Jahangiri M, Mohamed-Ali V. Epicardial adipokines in obesity and coronary artery disease induce atherogenic changes in monocytes and endothelial cells Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1340-6. doi: 10.1161/ATVBAHA.110.204719. Epub 2010 Apr 15. 3. Langheim S, Dreas L, Veschini L, Maisano F, Foglieni C, Ferrarello S, Sinagra G, Zingone B, Alfieri O, Ferrero E, Maseri A, Ruotolo G. Increased expression and secretion of resistin in epicardial adipose tissue of patients with acute coronary syndrome Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H746-53. doi: 10.1152/ajpheart.00617.2009. Epub 2010 Jan 8. 4. Ria F, Gallard A, Gabaglia CR, Guery JC, Sercarz EE, Adorini L: Selection of similar naive T cell repertoires but induction of distinct T cell responses by native and modified antigen. J Immunol 2004, 172:3447-3453. 5. Currier JR, Deulofeut H, Barron KS, Kehn PJ, Robinson MA: Mitogens, superantigens, and nominal antigens elicit distinctive patterns of TCRB CDR3 diversity. Hum Immunol 1996, 48:39-51. 6. Pannetier C, Cochet M, Darche S, Casrouge A, Zoller M, Kourilsky P: The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc Natl Acad Sci USA 1993, 90:4319-4323. 7. Ria F, Penitente R, De Santis M, Nicolò C, Di Sante G, Orsini M, Arzani D, Fattorossi A, Battaglia A, Ferraccioli GF. Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis.Arthritis Res Ther. 2008;10(6):R135. doi: 10.1186/ar2553. Epub 2008 Nov 17. 8. Freeman JD, Warren RL, Webb JR, Nelson BH, Holt RA. Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing. Genome Res. 2009 Oct;19(10):1817-24. doi: 10.1101/gr.092924.109. Epub 2009 Jun 18. 9. Ria F, Penitente R, De Santis M, Nicolò C, Di Sante G, Orsini M, Arzani D, Fattorossi A, Battaglia A, Ferraccioli GF. Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis.Arthritis Res Ther. 2008;10(6):R135. doi: 10.1186/ar2553. Epub 2008 Nov 17. Keywords: epicardial adipose tissue, T cell repertoire, Acute Coronary Syndrome, HLA Antigens, Adaptive immunity and cardiovascular disease Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Di Sante G, Liuzzo G, Severino A, Pazzano V, Pedicino D, Glieca F, Nicola L, Ria F and Crea F (2013). Specific oligoclonal T-cell recruitment within epicardial adipose tissue of patients with acute coronary syndrome: evidence for a local, immune-mediated, pathogenetic mechanism. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00726 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 14 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Gabriele Di Sante, Università Cattolica del Sacro Cuore - Policlinico Gemelli, General Pathology, Rome, Italy, gabriele.disante@hotmail.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Gabriele Di Sante Giovanna Liuzzo Anna Severino Vincenzo Pazzano Daniela Pedicino Franco Glieca Luciani Nicola Francesco Ria Filippo Crea Google Gabriele Di Sante Giovanna Liuzzo Anna Severino Vincenzo Pazzano Daniela Pedicino Franco Glieca Luciani Nicola Francesco Ria Filippo Crea Google Scholar Gabriele Di Sante Giovanna Liuzzo Anna Severino Vincenzo Pazzano Daniela Pedicino Franco Glieca Luciani Nicola Francesco Ria Filippo Crea PubMed Gabriele Di Sante Giovanna Liuzzo Anna Severino Vincenzo Pazzano Daniela Pedicino Franco Glieca Luciani Nicola Francesco Ria Filippo Crea Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
• W2330001346 created "2016-06-24" @default.
• W2330001346 creator A5015063200 @default.
• W2330001346 creator A5021620436 @default.
• W2330001346 creator A5030237178 @default.
• W2330001346 creator A5031505042 @default.
• W2330001346 creator A5032314426 @default.
• W2330001346 creator A5060562699 @default.
• W2330001346 creator A5064329135 @default.
• W2330001346 creator A5071172865 @default.
• W2330001346 creator A5088944331 @default.
• W2330001346 date "2013-01-01" @default.
• W2330001346 modified "2023-09-26" @default.
• W2330001346 title "Specific oligoclonal T-cell recruitment within epicardial adipose tissue of patients with acute coronary syndrome: evidence for a local, immune-mediated, pathogenetic mechanism" @default.
• W2330001346 doi "https://doi.org/10.3389/conf.fimmu.2013.02.00726" @default.
• W2330001346 hasPublicationYear "2013" @default.
• W2330001346 type Work @default.
• W2330001346 sameAs 2330001346 @default.
• W2330001346 citedByCount "0" @default.
• W2330001346 crossrefType "journal-article" @default.
• W2330001346 hasAuthorship W2330001346A5015063200 @default.
• W2330001346 hasAuthorship W2330001346A5021620436 @default.
• W2330001346 hasAuthorship W2330001346A5030237178 @default.
• W2330001346 hasAuthorship W2330001346A5031505042 @default.
• W2330001346 hasAuthorship W2330001346A5032314426 @default.
• W2330001346 hasAuthorship W2330001346A5060562699 @default.
• W2330001346 hasAuthorship W2330001346A5064329135 @default.
• W2330001346 hasAuthorship W2330001346A5071172865 @default.
• W2330001346 hasAuthorship W2330001346A5088944331 @default.
• W2330001346 hasBestOaLocation W23300013461 @default.
• W2330001346 hasConcept C111472728 @default.
• W2330001346 hasConcept C126322002 @default.
• W2330001346 hasConcept C138885662 @default.
• W2330001346 hasConcept C164705383 @default.
• W2330001346 hasConcept C171089720 @default.
• W2330001346 hasConcept C203014093 @default.
• W2330001346 hasConcept C2777698277 @default.
• W2330001346 hasConcept C2909906576 @default.
• W2330001346 hasConcept C500558357 @default.
• W2330001346 hasConcept C71924100 @default.
• W2330001346 hasConcept C8891405 @default.
• W2330001346 hasConcept C89611455 @default.
• W2330001346 hasConceptScore W2330001346C111472728 @default.
• W2330001346 hasConceptScore W2330001346C126322002 @default.
• W2330001346 hasConceptScore W2330001346C138885662 @default.
• W2330001346 hasConceptScore W2330001346C164705383 @default.
• W2330001346 hasConceptScore W2330001346C171089720 @default.
• W2330001346 hasConceptScore W2330001346C203014093 @default.
• W2330001346 hasConceptScore W2330001346C2777698277 @default.
• W2330001346 hasConceptScore W2330001346C2909906576 @default.
• W2330001346 hasConceptScore W2330001346C500558357 @default.
• W2330001346 hasConceptScore W2330001346C71924100 @default.
• W2330001346 hasConceptScore W2330001346C8891405 @default.
• W2330001346 hasConceptScore W2330001346C89611455 @default.
• W2330001346 hasLocation W23300013461 @default.
• W2330001346 hasOpenAccess W2330001346 @default.
• W2330001346 hasPrimaryLocation W23300013461 @default.
• W2330001346 hasRelatedWork W2031269965 @default.
• W2330001346 hasRelatedWork W2133964071 @default.
• W2330001346 hasRelatedWork W2187342990 @default.
• W2330001346 hasRelatedWork W2525778866 @default.
• W2330001346 hasRelatedWork W2560790490 @default.
• W2330001346 hasRelatedWork W2596660188 @default.
• W2330001346 hasRelatedWork W2737074397 @default.
• W2330001346 hasRelatedWork W2760815731 @default.
• W2330001346 hasRelatedWork W2761476198 @default.
• W2330001346 hasRelatedWork W3013716928 @default.
• W2330001346 hasVolume "4" @default.
• W2330001346 isParatext "false" @default.
• W2330001346 isRetracted "false" @default.
• W2330001346 magId "2330001346" @default.
• W2330001346 workType "article" @default.