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- W2330059830 abstract "Objectives The current optimal therapeutic approach in early rheumatoid arthritis (RA) is to start Methotrexate (MTX) to target inflammation and induce remission. Prediction of MTX therapy response remains a key clinical need to enable the identification of patients who would benefit from an alternative, more aggressive treatment strategy. T-cell subset analysis has been shown to have biomarker value in predicting MTX remission in early RA. 1 Given the clinical importance of these findings, our aim was to validate the original data 1 using T-cell subset quantification this time performed solemnly by routine hospital services, in order to replicate these original findings and validate naive T-cell frequencies as biomarker of the the achievement of clinical remission with MTX treatment in early RA. Methods T-cell subsets were quantified in 70 drug-naive early RA patients, commencing MTX. The primary outcome was remission (DAS28 Results Remission was achieved in 37/70 patients. In univariate analysis, the achievement of remission was strongly associated with age-corrected naive CD4 + T-cell frequency and current not-smoking (p Conclusion This study confirms the ability of baseline naive T-cell subset analysis in predicting early RA remission with first-line MTX therapy, suggesting clinical utility for the selection of the most appropriate therapy at disease presentation. All data being acquired by hospital routine services, they should be transferable widely towards personalised medicine. Reference Ponchel F, Goeb V, Parmar R, et al . An immunological biomarker to predict MTX response in early RA. Ann Rheum Dis 2014;73(11):2047–53" @default.
- W2330059830 created "2016-06-24" @default.
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- W2330059830 date "2016-02-01" @default.
- W2330059830 modified "2023-09-28" @default.
- W2330059830 title "A2.42 Clinical utility of measuring naÏve CD4+T-cell in early ra patient to predict remission on mtx: A replication study" @default.
- W2330059830 doi "https://doi.org/10.1136/annrheumdis-2016-209124.77" @default.
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