Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330092466> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2330092466 endingPage "107" @default.
- W2330092466 startingPage "97" @default.
- W2330092466 abstract "Sepsis is one of the most complex human diseases that continue to be associated with high mortality rates and substantial medical costs. It is an infection-induced, complex traits systemic syndrome that engages most of the bodys systems and organs. Whereas several etiologic agents can elicit sepsis, disease susceptibility, severity and therapeutic outcomes are modulated by a complex interaction of numerous environmental and constitutive (e.g., genomic) factors. To effectively understand and treat different types of sepsis in susceptible individuals, we need to adopt holistic systems approaches that utilize network-based investigations to integrate disease related complex traits, themselves affected by variations in the host genomic and epigenetic contexts, physiogenomic, metabolomic status as well as by variations in the pathogen. Importantly, a systems approach to sepsis can provide a roadmap to help identify both the host and the pathogen pathways underlying sepsis or variable therapeutic responses to sepsis. This paper introduces the emerging field of “septomics” – i.e., the application of high-throughput omics technologies to sepsis related complex traits - in diagnosing and/or modulating susceptibility and outcomes of sepsis. Additionally, we discuss how unbiased, network-based systems approaches and biotools can help better understand novel gene-by-environment interactions in sepsis, and identify genetic, physiologic and soluble (e.g., proteomics) biomarkers that can precisely predict disease susceptibility, progression or response to therapeutic interventions. Finally, we note that septomics also signals a new application of genome-based medicine in the context of global public health against existing and emerging infectious diseases that are greatly affecting the world populations in both developed and developing countries." @default.
- W2330092466 created "2016-06-24" @default.
- W2330092466 creator A5030225233 @default.
- W2330092466 date "2010-06-01" @default.
- W2330092466 modified "2023-09-23" @default.
- W2330092466 title "Septomics: Application of Systems Approaches to Sepsis - Potential for Personalized Management of Septic Patients" @default.
- W2330092466 doi "https://doi.org/10.2174/187569210791383910" @default.
- W2330092466 hasPublicationYear "2010" @default.
- W2330092466 type Work @default.
- W2330092466 sameAs 2330092466 @default.
- W2330092466 citedByCount "0" @default.
- W2330092466 crossrefType "journal-article" @default.
- W2330092466 hasAuthorship W2330092466A5030225233 @default.
- W2330092466 hasConcept C104317684 @default.
- W2330092466 hasConcept C126322002 @default.
- W2330092466 hasConcept C141231307 @default.
- W2330092466 hasConcept C151730666 @default.
- W2330092466 hasConcept C152662350 @default.
- W2330092466 hasConcept C163763905 @default.
- W2330092466 hasConcept C177713679 @default.
- W2330092466 hasConcept C189206191 @default.
- W2330092466 hasConcept C203014093 @default.
- W2330092466 hasConcept C2777628635 @default.
- W2330092466 hasConcept C2778384902 @default.
- W2330092466 hasConcept C2779134260 @default.
- W2330092466 hasConcept C2779343474 @default.
- W2330092466 hasConcept C32220436 @default.
- W2330092466 hasConcept C41091548 @default.
- W2330092466 hasConcept C54355233 @default.
- W2330092466 hasConcept C60644358 @default.
- W2330092466 hasConcept C70721500 @default.
- W2330092466 hasConcept C71924100 @default.
- W2330092466 hasConcept C86803240 @default.
- W2330092466 hasConceptScore W2330092466C104317684 @default.
- W2330092466 hasConceptScore W2330092466C126322002 @default.
- W2330092466 hasConceptScore W2330092466C141231307 @default.
- W2330092466 hasConceptScore W2330092466C151730666 @default.
- W2330092466 hasConceptScore W2330092466C152662350 @default.
- W2330092466 hasConceptScore W2330092466C163763905 @default.
- W2330092466 hasConceptScore W2330092466C177713679 @default.
- W2330092466 hasConceptScore W2330092466C189206191 @default.
- W2330092466 hasConceptScore W2330092466C203014093 @default.
- W2330092466 hasConceptScore W2330092466C2777628635 @default.
- W2330092466 hasConceptScore W2330092466C2778384902 @default.
- W2330092466 hasConceptScore W2330092466C2779134260 @default.
- W2330092466 hasConceptScore W2330092466C2779343474 @default.
- W2330092466 hasConceptScore W2330092466C32220436 @default.
- W2330092466 hasConceptScore W2330092466C41091548 @default.
- W2330092466 hasConceptScore W2330092466C54355233 @default.
- W2330092466 hasConceptScore W2330092466C60644358 @default.
- W2330092466 hasConceptScore W2330092466C70721500 @default.
- W2330092466 hasConceptScore W2330092466C71924100 @default.
- W2330092466 hasConceptScore W2330092466C86803240 @default.
- W2330092466 hasIssue "2" @default.
- W2330092466 hasLocation W23300924661 @default.
- W2330092466 hasOpenAccess W2330092466 @default.
- W2330092466 hasPrimaryLocation W23300924661 @default.
- W2330092466 hasRelatedWork W1978279746 @default.
- W2330092466 hasRelatedWork W1987948216 @default.
- W2330092466 hasRelatedWork W2005588132 @default.
- W2330092466 hasRelatedWork W2046590681 @default.
- W2330092466 hasRelatedWork W2132914709 @default.
- W2330092466 hasRelatedWork W2748327522 @default.
- W2330092466 hasRelatedWork W2893672911 @default.
- W2330092466 hasRelatedWork W2968281800 @default.
- W2330092466 hasRelatedWork W2995533571 @default.
- W2330092466 hasRelatedWork W4206712537 @default.
- W2330092466 hasVolume "8" @default.
- W2330092466 isParatext "false" @default.
- W2330092466 isRetracted "false" @default.
- W2330092466 magId "2330092466" @default.
- W2330092466 workType "article" @default.