Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330100567> ?p ?o ?g. }
- W2330100567 endingPage "1007" @default.
- W2330100567 startingPage "1001" @default.
- W2330100567 abstract "Intake of polyphenols and polyphenol-rich fruit extracts has been shown to reduce markers of inflammation, diabetes, and hepatic complications that result from the consumption of a high-fat (HF) diet.The objective of this study was to determine whether mice fed polyphenol-rich apple peel extract (AE), cherry extract (CE), and quercetin, a phytochemical abundant in fruits including apples and cherries, would modulate the harmful effects of adiposity on blood glucose regulation, endocrine concentrations, and hepatic metabolism in HF-fed C57BL/6J male mice.Groups of 8-wk-old mice (n = 8 each) were fed 5 diets for 10 wk, including low-fat (LF; 10% of total energy) and HF (60% of total energy) control diets and 3 HF diets containing polyphenol-rich AE, CE, and quercetin (0.2% wt:wt). Also, an in vitro study used HepG2 cells exposed to quercetin (0-100 μmol/L) to determine whether intracellular lipid accumulation could be modulated by this phytochemical.Mice fed the HF control diet consumed 36% more energy, gained 14 g more body weight, and had ∼50% elevated blood glucose concentrations (all P < 0.05) than did LF-fed mice. Mice fed HF diets containing AE, CE, or quercetin became as obese as HF-fed mice, but had significantly lower blood glucose concentrations after food deprivation (-36%, -22%, -22%, respectively; P < 0.05). Concentrations of serum C-reactive protein were reduced 29% in quercetin-fed mice compared with HF-fed controls (P < 0.05). A qualitative evaluation of liver tissue sections suggested that fruit phytochemicals may reduce hepatic lipid accumulation. A quantitative analysis of lipid accumulation in HepG2 cells demonstrated a dose-dependent decrease in lipid content in cells treated with 0-100 μmol quercetin/L (P < 0.05).In mice, consumption of AE, CE, or quercetin appears to modulate some of the harmful effects associated with the consumption of an obesogenic HF diet. Furthermore, in a cell culture model, quercetin was shown to reduce intracellular lipid accumulation in a dose-dependent fashion." @default.
- W2330100567 created "2016-06-24" @default.
- W2330100567 creator A5001478855 @default.
- W2330100567 creator A5009489350 @default.
- W2330100567 creator A5012116534 @default.
- W2330100567 creator A5024696577 @default.
- W2330100567 creator A5034551982 @default.
- W2330100567 creator A5047170003 @default.
- W2330100567 creator A5057323244 @default.
- W2330100567 creator A5074597602 @default.
- W2330100567 date "2016-05-01" @default.
- W2330100567 modified "2023-10-07" @default.
- W2330100567 title "Consumption of Quercetin and Quercetin-Containing Apple and Cherry Extracts Affects Blood Glucose Concentration, Hepatic Metabolism, and Gene Expression Patterns in Obese C57BL/6J High Fat–Fed Mice" @default.
- W2330100567 cites W1955371799 @default.
- W2330100567 cites W1977371315 @default.
- W2330100567 cites W1982201682 @default.
- W2330100567 cites W1988814980 @default.
- W2330100567 cites W1990718598 @default.
- W2330100567 cites W1994192313 @default.
- W2330100567 cites W1995375315 @default.
- W2330100567 cites W2014418136 @default.
- W2330100567 cites W2019611553 @default.
- W2330100567 cites W2022254944 @default.
- W2330100567 cites W2046859247 @default.
- W2330100567 cites W2054356183 @default.
- W2330100567 cites W2076596080 @default.
- W2330100567 cites W2079080809 @default.
- W2330100567 cites W2083754959 @default.
- W2330100567 cites W2089565237 @default.
- W2330100567 cites W2094395909 @default.
- W2330100567 cites W2104639995 @default.
- W2330100567 cites W2106010278 @default.
- W2330100567 cites W2106711877 @default.
- W2330100567 cites W2112118938 @default.
- W2330100567 cites W2125121177 @default.
- W2330100567 cites W2130630748 @default.
- W2330100567 cites W2131349789 @default.
- W2330100567 cites W2134153332 @default.
- W2330100567 cites W2134668843 @default.
- W2330100567 cites W2138413405 @default.
- W2330100567 cites W2138521217 @default.
- W2330100567 cites W2139135476 @default.
- W2330100567 cites W2151922379 @default.
- W2330100567 cites W2157015549 @default.
- W2330100567 cites W2157406373 @default.
- W2330100567 cites W2157433311 @default.
- W2330100567 cites W2170508257 @default.
- W2330100567 doi "https://doi.org/10.3945/jn.115.228817" @default.
- W2330100567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4841928" @default.
- W2330100567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27052533" @default.
- W2330100567 hasPublicationYear "2016" @default.
- W2330100567 type Work @default.
- W2330100567 sameAs 2330100567 @default.
- W2330100567 citedByCount "54" @default.
- W2330100567 countsByYear W23301005672016 @default.
- W2330100567 countsByYear W23301005672017 @default.
- W2330100567 countsByYear W23301005672018 @default.
- W2330100567 countsByYear W23301005672019 @default.
- W2330100567 countsByYear W23301005672020 @default.
- W2330100567 countsByYear W23301005672021 @default.
- W2330100567 countsByYear W23301005672022 @default.
- W2330100567 countsByYear W23301005672023 @default.
- W2330100567 crossrefType "journal-article" @default.
- W2330100567 hasAuthorship W2330100567A5001478855 @default.
- W2330100567 hasAuthorship W2330100567A5009489350 @default.
- W2330100567 hasAuthorship W2330100567A5012116534 @default.
- W2330100567 hasAuthorship W2330100567A5024696577 @default.
- W2330100567 hasAuthorship W2330100567A5034551982 @default.
- W2330100567 hasAuthorship W2330100567A5047170003 @default.
- W2330100567 hasAuthorship W2330100567A5057323244 @default.
- W2330100567 hasAuthorship W2330100567A5074597602 @default.
- W2330100567 hasBestOaLocation W23301005671 @default.
- W2330100567 hasConcept C126322002 @default.
- W2330100567 hasConcept C134018914 @default.
- W2330100567 hasConcept C171089720 @default.
- W2330100567 hasConcept C185592680 @default.
- W2330100567 hasConcept C195475562 @default.
- W2330100567 hasConcept C2776175234 @default.
- W2330100567 hasConcept C2778004101 @default.
- W2330100567 hasConcept C2781263971 @default.
- W2330100567 hasConcept C4733338 @default.
- W2330100567 hasConcept C55493867 @default.
- W2330100567 hasConcept C555293320 @default.
- W2330100567 hasConcept C62231903 @default.
- W2330100567 hasConcept C70899900 @default.
- W2330100567 hasConcept C71924100 @default.
- W2330100567 hasConcept C86803240 @default.
- W2330100567 hasConceptScore W2330100567C126322002 @default.
- W2330100567 hasConceptScore W2330100567C134018914 @default.
- W2330100567 hasConceptScore W2330100567C171089720 @default.
- W2330100567 hasConceptScore W2330100567C185592680 @default.
- W2330100567 hasConceptScore W2330100567C195475562 @default.
- W2330100567 hasConceptScore W2330100567C2776175234 @default.
- W2330100567 hasConceptScore W2330100567C2778004101 @default.
- W2330100567 hasConceptScore W2330100567C2781263971 @default.
- W2330100567 hasConceptScore W2330100567C4733338 @default.
- W2330100567 hasConceptScore W2330100567C55493867 @default.
- W2330100567 hasConceptScore W2330100567C555293320 @default.