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- W2330134469 abstract "Summary Endothelin-1 (ET-1) was shown to exert direct cardiac effects by complex signaling pathways and to interact with neurotransmitter regulation of cardiac activity. The effect of ET-1 was investigated on the β-adrenergic stimulation of cardiac L-type Ca2+ current (ICaL) on isolated rat atrial myocytes by using the patch-clamp technique. ET-1 (5 × 10-8M) reversed the increase in ICaL induced by isoprenaline (10-6M) but had no effect on basal ICaL and on (-) Bay K 8644-increased ICaL(10-6M); so ET-1 might exert an effect only when the Ca2+ channels are phosphorylated. The antiadrenergic action of ET-1, blocked by BQ-123 (10-6M) and unaffected by IRL 1038 (3.5 × 10-8M) should be mediated by ET-A receptors. The inhibitory action of ET-1 was still observed when ICaL was previously increased by forskolin (3 × 10-6M), 8-bromo-cyclic adenosine monophosphate (8-Br-cAMP; 200 μM), or cAMP (100 μM) in presence of isobutyl methyl xanthine (IBMX; 10-6M), suggesting that the antiadrenergic action of ET-1 on ICaL was exerted independent of the cAMP-dependent phosphorylation pathway. ET-1 is known to be an activator of phosphoinositide hydrolysis, resulting in an increased production of IP3 and diacylglycerol (DAG). A Ca2+-dependent inhibition of ICaL consequently to an elevation of the intracellular Ca2+ pool via IP3 might be excluded in the action of ET-1, because of the presence of EGTA in the intrapipette medium. ET-1 reversed the isoprenaline-induced increase in ICaL in the presence of protein kinase C inhibitor [PKC(19-31); 100 μM), making unlikely the involvement of a DAG-dependent activation of PKC. Therefore the antiadrenergic action of ET-1 might also be independent on the phosphoinositide pathway." @default.
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- W2330134469 date "1997-01-01" @default.
- W2330134469 modified "2023-09-25" @default.
- W2330134469 title "Endothelin-1 Inhibits L-Type Ca2+ Current Enhanced by Isoprenaline in Rat Atrial Myocytes" @default.
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- W2330134469 doi "https://doi.org/10.1097/00005344-199701000-00021" @default.
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