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• W2330149011 abstract "In Brief Background: During pars plana vitrectomy, the retina is exposed to several iatrogenic risk factors, including excitotoxicity. A taurine-containing irrigation solution for pars plana vitrectomy (PURI PROTECT) has been developed and is claimed to have neuroprotective properties. Methods: Retinal ganglion cells (RGC-5) and retinal whole mounts were incubated in standard irrigation solution (SIS) and SIS supplemented with 3 mM taurine (SIS-taurine). Excitotoxicity was induced by the addition of 8, 10, and 12 mM or 250 μM glutamate. Cell viability and cell survival were assessed by the MTT test and Annexin-V/propidium iodide flow cytometry. Whole mounts were stained with the Live/Dead staining assay. Pars plana vitrectomy with SIS or SIS-taurine was performed in rabbits. Animals were followed-up by electroretinography. Results: RGC-5 incubated in SIS-taurine showed a 4.3-fold (P < 0.0005) better overall cell viability and an up to 8.5-fold (P < 0.05) increased cell survival under excitotoxic conditions compared with that incubated in SIS. Whole mounts incubated in SIS-taurine showed a 1.7-fold (P < 0.0005) and 1.6-fold (P < 0.0005) better cell survival under excitotoxic and nonexcitotoxic conditions, respectively. In the immediate postoperative period, b-wave amplitudes were significantly better in animals operated with SIS-taurine compared with control (P < 0.01). Conclusion: A taurine-containing irrigation solution may protect retinal ganglion cells against excitotoxicity. The new irrigation solution for vitrectomy PURI PROTECT is claimed to be neuroprotective because of the addition of taurine. No studies exist concerning its potential neuroprotective effects. In cell culture and ex vivo experiments with retinal ganglion cells (RGC-5) and whole-mount preparations, taurine effectively protected retinal ganglion cells against excitotoxicity." @default.
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• W2330149011 date "2012-07-01" @default.
• W2330149011 modified "2023-09-26" @default.
• W2330149011 title "NEUROPROTECTIVE EFFECTS OF A TAURINE-CONTAINING IRRIGATION SOLUTION FOR VITRECTOMY" @default.
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• W2330149011 doi "https://doi.org/10.1097/iae.0b013e318232c37c" @default.
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