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- W2330159253 abstract "Little is known of the gene regulatory mechanisms that coordinate the contractile and metabolic specializations of skeletal muscle fibers. Here we report a novel connection between fast isoform contractile protein transgene and glycolytic enzyme expression. In quantitative histochemical studies of transgenic mouse muscle fibers, we found extensive coregulation of the glycolytic enzyme glycerol-3-phosphate dehydrogenase (GPDH) and transgene constructs based on the fast skeletal muscle troponin I (TnIfast) gene. In addition to a common IIB > IIX > IIA fiber type pattern, TnIfast transgenes and GPDH showed correlated fiber-to-fiber variation within each fast fiber type, concerted emergence of high-level expression during early postnatal muscle maturation, and parallel responses to muscle under- or overloading. Regulatory information for GPDH-coregulated expression is carried by the TnIfast first-intron enhancer (IRE). These results identify an unexpected contractile/metabolic gene regulatory link that is amenable to further molecular characterization. They also raise the possibility that the equal expression in all fast fiber types observed for the endogenous TnIfast gene may be driven by different metabolically coordinated mechanisms in glycolytic (IIB) vs. oxidative (IIA) fast fibers." @default.
- W2330159253 created "2016-06-24" @default.
- W2330159253 creator A5048720986 @default.
- W2330159253 creator A5070473067 @default.
- W2330159253 date "2002-01-01" @default.
- W2330159253 modified "2023-09-23" @default.
- W2330159253 title "Coregulation of fast contractile protein transgene and glycolytic enzyme expression in mouse skeletal muscle" @default.
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- W2330159253 doi "https://doi.org/10.1152/ajpcell.00294.2001" @default.
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