FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330210822> ?p ?o ?g. }

• W2330210822 endingPage "18" @default.
• W2330210822 startingPage "1" @default.
• W2330210822 abstract "Trimethyltin chloride (TMT) is a classic neurotoxicant that can cause severe neurodegenerative diseases. Some signaling pathways involving cell death play pivotal roles in the central nervous system. In this study, the role of Sonic Hedgehog (Shh) and PI3K/Akt pathways in TMT-induced apoptosis and protective effect of Lycium barbarum polysaccharides (LBP) on mouse neuro-2a (N2a) cells were investigated. Results showed that TMT treatment significantly enhanced apoptosis, upregulated proapoptotic Bax, downregulated antiapoptotic Bcl-2 expression, and increased caspase-3 activity in a dose-dependent manner in N2a cells. TMT induced oxidative stress in cells, performing reactive oxygen species (ROS) and malondialdehyde (MDA) excessive generation, and superoxide dismutase (SOD) activity reduction. TMT significantly decreased phosphorylated glycogen synthase kinase-3β (GSK-3β) and inhibited Shh and PI3K/Akt pathways. However, the addition of LBP upregulated GSK-3β phosphorylation, activated Shh and PI3K/Akt pathways, and eventually reduced apoptosis and oxidative stress caused by TMT. The interaction between Shh and PI3K/Akt pathways was clarified by specific PI3K inhibitor LY294002 or Shh inhibitor GDC-0449. Moreover, LY294002 and GDC-0449 pretreatment both induced phosphorylated GSK-3β downregulation and significantly promoted apoptosis induced by TMT. These results suggest that LBP could reduce TMT-induced N2a cells apoptosis by regulating GSK-3β phosphorylation, Shh, and PI3K/Akt signaling pathways." @default.
• W2330210822 created "2016-06-24" @default.
• W2330210822 creator A5014125467 @default.
• W2330210822 creator A5025685483 @default.
• W2330210822 creator A5029529654 @default.
• W2330210822 creator A5084442648 @default.
• W2330210822 creator A5086326013 @default.
• W2330210822 date "2016-01-01" @default.
• W2330210822 modified "2023-09-27" @default.
• W2330210822 title "<i>Lycium barbarum</i>Polysaccharides Protect against Trimethyltin Chloride-Induced Apoptosis via Sonic Hedgehog and PI3K/Akt Signaling Pathways in Mouse Neuro-2a Cells" @default.
• W2330210822 cites W1965664422 @default.
• W2330210822 cites W1981623512 @default.
• W2330210822 cites W1982862374 @default.
• W2330210822 cites W1983072310 @default.
• W2330210822 cites W1994122995 @default.
• W2330210822 cites W1994144722 @default.
• W2330210822 cites W1995024997 @default.
• W2330210822 cites W2002670541 @default.
• W2330210822 cites W2002956073 @default.
• W2330210822 cites W2003752694 @default.
• W2330210822 cites W2005328929 @default.
• W2330210822 cites W2008885970 @default.
• W2330210822 cites W2016338155 @default.
• W2330210822 cites W2017412040 @default.
• W2330210822 cites W2019665288 @default.
• W2330210822 cites W2020253538 @default.
• W2330210822 cites W2025284997 @default.
• W2330210822 cites W2025583462 @default.
• W2330210822 cites W2029228776 @default.
• W2330210822 cites W2032212320 @default.
• W2330210822 cites W2035376760 @default.
• W2330210822 cites W2048069434 @default.
• W2330210822 cites W2052326424 @default.
• W2330210822 cites W2066860513 @default.
• W2330210822 cites W2074808874 @default.
• W2330210822 cites W2081733368 @default.
• W2330210822 cites W2085465557 @default.
• W2330210822 cites W2085621010 @default.
• W2330210822 cites W2091885208 @default.
• W2330210822 cites W2111088386 @default.
• W2330210822 cites W2118208417 @default.
• W2330210822 cites W2119120682 @default.
• W2330210822 cites W2156710947 @default.
• W2330210822 cites W2162059985 @default.
• W2330210822 cites W2168480444 @default.
• W2330210822 cites W2330968727 @default.
• W2330210822 cites W4233746381 @default.
• W2330210822 doi "https://doi.org/10.1155/2016/9826726" @default.
• W2330210822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4838808" @default.
• W2330210822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27143997" @default.
• W2330210822 hasPublicationYear "2016" @default.
• W2330210822 type Work @default.
• W2330210822 sameAs 2330210822 @default.
• W2330210822 citedByCount "27" @default.
• W2330210822 countsByYear W23302108222017 @default.
• W2330210822 countsByYear W23302108222018 @default.
• W2330210822 countsByYear W23302108222019 @default.
• W2330210822 countsByYear W23302108222020 @default.
• W2330210822 countsByYear W23302108222022 @default.
• W2330210822 countsByYear W23302108222023 @default.
• W2330210822 crossrefType "journal-article" @default.
• W2330210822 hasAuthorship W2330210822A5014125467 @default.
• W2330210822 hasAuthorship W2330210822A5025685483 @default.
• W2330210822 hasAuthorship W2330210822A5029529654 @default.
• W2330210822 hasAuthorship W2330210822A5084442648 @default.
• W2330210822 hasAuthorship W2330210822A5086326013 @default.
• W2330210822 hasBestOaLocation W23302108221 @default.
• W2330210822 hasConcept C104317684 @default.
• W2330210822 hasConcept C104629339 @default.
• W2330210822 hasConcept C11960822 @default.
• W2330210822 hasConcept C127561419 @default.
• W2330210822 hasConcept C182996813 @default.
• W2330210822 hasConcept C185592680 @default.
• W2330210822 hasConcept C190283241 @default.
• W2330210822 hasConcept C2775838275 @default.
• W2330210822 hasConcept C2776151105 @default.
• W2330210822 hasConcept C2776637008 @default.
• W2330210822 hasConcept C2776912716 @default.
• W2330210822 hasConcept C48349386 @default.
• W2330210822 hasConcept C502942594 @default.
• W2330210822 hasConcept C55493867 @default.
• W2330210822 hasConcept C62478195 @default.
• W2330210822 hasConcept C75217442 @default.
• W2330210822 hasConcept C86554907 @default.
• W2330210822 hasConcept C86803240 @default.
• W2330210822 hasConcept C95444343 @default.
• W2330210822 hasConceptScore W2330210822C104317684 @default.
• W2330210822 hasConceptScore W2330210822C104629339 @default.
• W2330210822 hasConceptScore W2330210822C11960822 @default.
• W2330210822 hasConceptScore W2330210822C127561419 @default.
• W2330210822 hasConceptScore W2330210822C182996813 @default.
• W2330210822 hasConceptScore W2330210822C185592680 @default.
• W2330210822 hasConceptScore W2330210822C190283241 @default.
• W2330210822 hasConceptScore W2330210822C2775838275 @default.
• W2330210822 hasConceptScore W2330210822C2776151105 @default.
• W2330210822 hasConceptScore W2330210822C2776637008 @default.
• W2330210822 hasConceptScore W2330210822C2776912716 @default.
• W2330210822 hasConceptScore W2330210822C48349386 @default.

• next