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• W2330226503 startingPage "e0152641" @default.
• W2330226503 abstract "Promiscuous expression of tissue restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is crucial for negative selection of self-reactive T cells to establish central tolerance. Intercellular transfer of self-peptide-MHC complexes from mTECs to thymic dendritic cells (DCs) allows DCs to acquire TRAs, which in turn contributes to negative selection and regulatory T cell generation. However, mTECs are unlikely to express all TRAs, such as immunoglobulins generated only in B cells after somatic recombination, hyper-mutation, or class-switches. We report here that both mTECs and cortical TECs can efficiently acquire not only cell surface but also intracellular proteins from thymocytes. This reveals a previously unappreciated intercellular sharing of molecules from thymocytes to TECs, which may broaden the TRA inventory in mTECs for establishing a full spectrum of central tolerance." @default.
• W2330226503 created "2016-06-24" @default.
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• W2330226503 date "2016-03-29" @default.
• W2330226503 modified "2023-10-16" @default.
• W2330226503 title "Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells" @default.
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• W2330226503 doi "https://doi.org/10.1371/journal.pone.0152641" @default.
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