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- W2330232161 abstract "ラットの足蹠にcarrageenin, compound48/80あるいはadjvantを注射すると, 一定時間後の血漿にprostaglandin E2生合成の阻害作用およびhaptoglobin値の増加が認められた.一方, 部分精製したhaptoglobinはarachidonic acidを基質とするprostaglandin E2生合成を用量依存性に阻害した.ウシ精嚢microsomeの精製酵素を用いてその作用機作を検討したところ, haptoglobinが活性化因子のhemeと相互作用して阻害作用を示すことが明らかになった.しかし, prostaglandin E2生合成に対して阻害作用を示すhaptoglobin濃度 (ID50) は, 炎症ラット血漿では11μg/mlであるのに対して, 部分精製したhaptoglobinでは175μg/mlであり, 炎症ラット血漿の阻害作用をhaptoglobinのみで説明できないことが示唆された." @default.
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- W2330232161 date "1981-01-01" @default.
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- W2330232161 title "Inhibition of prostaglandin synthesizing enzymes by haptoglobin and plasma of rat with inflammation" @default.
- W2330232161 doi "https://doi.org/10.2492/jsir1981.1.105" @default.
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