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• W2330246735 endingPage "796" @default.
• W2330246735 startingPage "789" @default.
• W2330246735 abstract "Cell surface glycans are critical mediators of cell–cell, cell–ligand, and cell–pathogen interactions. By controlling the set of glycans displayed on the surface of a cell, it is possible to gain insight into the biological functions of glycans. Moreover, control of glycan expression can be used to direct cellular behavior. While genetic approaches to manipulate glycosyltransferase gene expression are available, their utility in glycan engineering has limitations due to the combinatorial nature of glycan biosynthesis and the functional redundancy of glycosyltransferase genes. Biochemical and chemical strategies offer valuable complements to these genetic approaches, notably by enabling introduction of unnatural functionalities, such as fluorophores, into cell surface glycans. Here, we describe some of the most recent developments in glycoengineering of cell surfaces, with an emphasis on strategies that employ novel chemical reagents. We highlight key examples of how these advances in cell surface glycan engineering enable study of cell surface glycans and their function. Exciting new technologies include synthetic lipid-glycans, new chemical reporters for metabolic oligosaccharide engineering to allow tandem and in vivo labeling of glycans, improved chemical and enzymatic methods for glycoproteomics, and metabolic glycosyltransferase inhibitors. Many chemical and biochemical reagents for glycan engineering are commercially available, facilitating their adoption by the biological community." @default.
• W2330246735 created "2016-06-24" @default.
• W2330246735 creator A5013990004 @default.
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• W2330246735 date "2016-04-10" @default.
• W2330246735 modified "2023-10-01" @default.
• W2330246735 title "Advances in cell surface glycoengineering reveal biological function" @default.
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• W2330246735 doi "https://doi.org/10.1093/glycob/cww045" @default.
• W2330246735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5018048" @default.
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• W2330246735 hasPublicationYear "2016" @default.
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