FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330256592> ?p ?o ?g. }

• W2330256592 endingPage "149" @default.
• W2330256592 startingPage "145" @default.
• W2330256592 abstract "Circulatory homeostasis is associated with interactions between multiple organs, and the disruption of dynamic circulatory homeostasis could be considered as heart failure. The brain is the central unit integrating neural and neurohormonal information from peripheral organs and controlling peripheral organs using the autonomic nervous system. Heart failure is worsened by abnormal sympathoexcitation associated with baroreflex failure and/or chemoreflex activation, and by vagal withdrawal, and autonomic modulation therapies have benefits for heart failure. Recently, we showed that baroreflex failure induces striking volume intolerance independent of left ventricular dysfunction. Many studies have indicated that an overactive renin-angiotensin system, excess oxidative stress and excess inflammation, and/or decreased nitric oxide in the brain cause sympathoexcitation in heart failure. We have demonstrated that angiotensin II type 1 receptor (AT1R)-induced oxidative stress in the rostral ventrolateral medulla (RVLM), which is known as a vasomotor center, causes prominent sympathoexcitation in heart failure model rats. Interestingly, systemic infusion of angiotensin II directly affects brain AT1R with sympathoexcitation and left ventricular diastolic dysfunction. Moreover, we have demonstrated that targeted deletion of AT1R in astrocytes strikingly improved survival with prevention of left ventricular remodeling and sympathoinhibition in myocardial infarction-induced heart failure. From these results, we believe it is possible that AT1R in astrocytes, not in neurons, have a key role in the pathophysiology of heart failure. We would like to propose a novel concept that the brain works as a central processing unit integrating neural and hormonal input, and that the disruption of dynamic circulatory homeostasis mediated by the brain causes heart failure." @default.
• W2330256592 created "2016-06-24" @default.
• W2330256592 creator A5009932847 @default.
• W2330256592 date "2016-01-01" @default.
• W2330256592 modified "2023-10-18" @default.
• W2330256592 title "Heart Failure as a Disruption of Dynamic Circulatory Homeostasis Mediated by the Brain" @default.
• W2330256592 cites W1493092704 @default.
• W2330256592 cites W155312217 @default.
• W2330256592 cites W1767967844 @default.
• W2330256592 cites W1816941720 @default.
• W2330256592 cites W1943576895 @default.
• W2330256592 cites W1965000519 @default.
• W2330256592 cites W1966409424 @default.
• W2330256592 cites W1967966894 @default.
• W2330256592 cites W1974559531 @default.
• W2330256592 cites W1975139989 @default.
• W2330256592 cites W1976824259 @default.
• W2330256592 cites W1979553650 @default.
• W2330256592 cites W1980285891 @default.
• W2330256592 cites W1987619509 @default.
• W2330256592 cites W1989570869 @default.
• W2330256592 cites W1989796023 @default.
• W2330256592 cites W1992102236 @default.
• W2330256592 cites W1992561032 @default.
• W2330256592 cites W1994172493 @default.
• W2330256592 cites W2004349171 @default.
• W2330256592 cites W2009544395 @default.
• W2330256592 cites W2012264947 @default.
• W2330256592 cites W2012619772 @default.
• W2330256592 cites W2014443512 @default.
• W2330256592 cites W2029012272 @default.
• W2330256592 cites W2034219963 @default.
• W2330256592 cites W2044518616 @default.
• W2330256592 cites W2045812078 @default.
• W2330256592 cites W2052825136 @default.
• W2330256592 cites W2054092125 @default.
• W2330256592 cites W2060988580 @default.
• W2330256592 cites W2067587317 @default.
• W2330256592 cites W2068519950 @default.
• W2330256592 cites W2074578583 @default.
• W2330256592 cites W2074718841 @default.
• W2330256592 cites W2076772461 @default.
• W2330256592 cites W2078614037 @default.
• W2330256592 cites W2080671217 @default.
• W2330256592 cites W2083212512 @default.
• W2330256592 cites W2091402272 @default.
• W2330256592 cites W2092274669 @default.
• W2330256592 cites W2096601585 @default.
• W2330256592 cites W2096723576 @default.
• W2330256592 cites W2097757382 @default.
• W2330256592 cites W2098688920 @default.
• W2330256592 cites W2099549518 @default.
• W2330256592 cites W2101791328 @default.
• W2330256592 cites W2108684086 @default.
• W2330256592 cites W2109011905 @default.
• W2330256592 cites W2109984600 @default.
• W2330256592 cites W2111498814 @default.
• W2330256592 cites W2114012278 @default.
• W2330256592 cites W2116774706 @default.
• W2330256592 cites W2120240698 @default.
• W2330256592 cites W2120533816 @default.
• W2330256592 cites W2121278286 @default.
• W2330256592 cites W2122092748 @default.
• W2330256592 cites W2122290203 @default.
• W2330256592 cites W2122749049 @default.
• W2330256592 cites W2123956361 @default.
• W2330256592 cites W2124270134 @default.
• W2330256592 cites W2124306044 @default.
• W2330256592 cites W2129967926 @default.
• W2330256592 cites W2134248006 @default.
• W2330256592 cites W2135393285 @default.
• W2330256592 cites W2139368311 @default.
• W2330256592 cites W2139540538 @default.
• W2330256592 cites W2143961764 @default.
• W2330256592 cites W21478844 @default.
• W2330256592 cites W2149646115 @default.
• W2330256592 cites W2153478909 @default.
• W2330256592 cites W2154942675 @default.
• W2330256592 cites W2155853691 @default.
• W2330256592 cites W2162881296 @default.
• W2330256592 cites W2164126712 @default.
• W2330256592 cites W2165846953 @default.
• W2330256592 cites W2169584791 @default.
• W2330256592 cites W2172025889 @default.
• W2330256592 cites W2201970982 @default.
• W2330256592 cites W2764148593 @default.
• W2330256592 cites W3937360 @default.
• W2330256592 cites W52877415 @default.
• W2330256592 doi "https://doi.org/10.1536/ihj.15-517" @default.
• W2330256592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26973279" @default.
• W2330256592 hasPublicationYear "2016" @default.
• W2330256592 type Work @default.
• W2330256592 sameAs 2330256592 @default.
• W2330256592 citedByCount "20" @default.
• W2330256592 countsByYear W23302565922016 @default.
• W2330256592 countsByYear W23302565922017 @default.
• W2330256592 countsByYear W23302565922018 @default.
• W2330256592 countsByYear W23302565922019 @default.

• next