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• W2330258675 abstract "You have accessJournal of UrologyProstate Cancer: Localized (IV)1 Apr 20131001 PREOPERATIVE PREDICTIVE FACTORS AND FURTHER RISK STRATIFICATION OF BIOCHEMICAL RECURRENCE IN CLINICALLY LOCALIZED HIGH RISK PROSTATE CANCER Riu Hamada, Jun Nakashima, Takeshi Hashimoto, Naoya Satake, Yoshihiro Nakagami, Choichiro Ozu, Yoshio Ohno, Yutaka Horiguchi, Kazunori Namiki, Kunihiko Yoshioka, Makoto Ohori, and Masaaki Tachibana Riu HamadaRiu Hamada Tokyo, Japan More articles by this author , Jun NakashimaJun Nakashima Tokyo, Japan More articles by this author , Takeshi HashimotoTakeshi Hashimoto Tokyo, Japan More articles by this author , Naoya SatakeNaoya Satake Tokyo, Japan More articles by this author , Yoshihiro NakagamiYoshihiro Nakagami Tokyo, Japan More articles by this author , Choichiro OzuChoichiro Ozu Tokyo, Japan More articles by this author , Yoshio OhnoYoshio Ohno Tokyo, Japan More articles by this author , Yutaka HoriguchiYutaka Horiguchi Tokyo, Japan More articles by this author , Kazunori NamikiKazunori Namiki Tokyo, Japan More articles by this author , Kunihiko YoshiokaKunihiko Yoshioka Tokyo, Japan More articles by this author , Makoto OhoriMakoto Ohori Tokyo, Japan More articles by this author , and Masaaki TachibanaMasaaki Tachibana Tokyo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.585AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES High risk prostate cancer may includes various patient groups. The present study was undertaken to identify preoperative predictive parameters of biochemical recurrence (BR) and to further stratify its risk in patients with high risk localized prostate cancer treated with radical prostatectomy (RP). METHODS The study population included 139 men with high risk prostate cancer (D'Amico risk classification) treated with RP alone. Estimates of BR were generated with a Kaplan-Meier method. Cox proportional hazards regression was used to examine preoperative predictors for BR. RESULTS Univariate analyses showed that prostate volume, transition zone volume and biopsy Gleason score were not significantly associated with BR. On the other hand, patients with preoperative PSA value ≥23ng/ml, PSA density (PSAD) ≥0.3, PSA density of trasition zone (PSATZD) ≥0.85, the total percentage of cores positive ≥37 % and the percentage of cores positive from the dominant side ≥70% showed significantly higher BR rates than their respective counterpart. Multivariate analysis demonstrated that the percentage of cores positive from the dominant side and PSATZD are significant independent prognostic factors for BR. Using these significant variables, the relative risk (RR) of BR could be expressed with the formula, exp (1.03 × the percentage of cores positive from the dominant side + 0.54 × PSATZD). The patients were stratified into three risk groups ; Group 1 (the percentage of cores positive from the dominant side <70% and PSATZD <0.85), Group 2 (the percentage of cores positive from the dominant side ≥70% and PSATZD <0.85, or the percentage of cores positive from the dominant side <70% and PSATZD ≥0.85), Group 3 (the percentage of cores positive from the dominant side ≥70% and PSATZD ≥0.85). There were significant differences in the BR rate among these groups (Figure). CONCLUSIONS Patients with localized high risk prostate cancer by the currently available definition do not have a uniformly poor prognosis after RP. The percentage of cores positive from the dominant side and PSATZD are significant predictors for BR and can provide the further stratification model to enable urologists to identify high risk patients with really poor prognosis. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e411 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.Metrics Author Information Riu Hamada Tokyo, Japan More articles by this author Jun Nakashima Tokyo, Japan More articles by this author Takeshi Hashimoto Tokyo, Japan More articles by this author Naoya Satake Tokyo, Japan More articles by this author Yoshihiro Nakagami Tokyo, Japan More articles by this author Choichiro Ozu Tokyo, Japan More articles by this author Yoshio Ohno Tokyo, Japan More articles by this author Yutaka Horiguchi Tokyo, Japan More articles by this author Kazunori Namiki Tokyo, Japan More articles by this author Kunihiko Yoshioka Tokyo, Japan More articles by this author Makoto Ohori Tokyo, Japan More articles by this author Masaaki Tachibana Tokyo, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2330258675 title "1001 PREOPERATIVE PREDICTIVE FACTORS AND FURTHER RISK STRATIFICATION OF BIOCHEMICAL RECURRENCE IN CLINICALLY LOCALIZED HIGH RISK PROSTATE CANCER" @default.
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