Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330260970> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2330260970 abstract "Dear Editor,Salmonella enterica serovar typhi, is endemic in India. Since 1990′s Fluoroquinolones (ciprofloxacin, ofloxacin) had been effective for multidrug resistant (MDR) strains, resistant to Ampicillin, Chloramphenical and Co-trimoxazole (ACCo). Presently however, many isolates of Salmonella, MDR and non-MDR show delayed response to ciprofloxacin [1, 2]. In UK, decreased sensitivity to ciprofloxacin increased from 2.7% in 1995 to 23% in 1999 [1]. An increase in Minimum Inhibitory Concentration (MIC) of ciprofloxacin (0.004-0.0039 mg/L in 1990 to 0.19-0.2 mg/L in 2003) has also been noted in India [2]. This is attributed to point-mutation in quinolone resistance determining region (QRDR) of topoisomerase gene, gyrA in Salmonella and leads to simultaneous resistance against nalidixic acid, a non-fluorinated narrow-spectrum quinolone [1]. Resistance to 30 μg nalidixic acid disc (zone diam 128 mg/L). Disk strengths and zone interpretations were in accordance with National Committee for Clinical Laboratory Standards (NCCLS). Out of 21 strains, 14 were known MDR isolates and 7 were sensitive strains. MIC for ciprofloxacin was raised in all, being 0.5 mg/L in 16 isolates (9MDR strains) and 1.0 mg/L in 5 isolates (all MDR strainsand all 7 sensitive strains). An MIC of >0.125 mg/L of ciprofloxacin has been associated with poor clinical response in several studies [1, 2, 4, 5]. These stains will either respond poorly or inappreciably to ciprofloxacin in-vivo, even if found sensitive invitro using 5 μg ciprofloxacin disc [3]. The current NCCLS breakpoints may have to be reevaluated for Salmonellae [3, 5]. These strains respond well to ceftriaxone or azithromycin [1, 2, 4]. Laboratories should look for nalidixic acid resistance in Salmonella isolates as a surrogate marker of decreased fluoroquinolone susceptibility and alert the physician. A blood culture is a must before starting any antibiotic in suspected enteric fever so that diagnosis is confirmed and the strain made available to the laboratory for further characterization." @default.
- W2330260970 created "2016-06-24" @default.
- W2330260970 creator A5025849953 @default.
- W2330260970 creator A5026513387 @default.
- W2330260970 creator A5055871161 @default.
- W2330260970 creator A5063242099 @default.
- W2330260970 creator A5074102236 @default.
- W2330260970 date "2005-07-01" @default.
- W2330260970 modified "2023-10-17" @default.
- W2330260970 title "Quinolones Losing Favour in Enteric Fever" @default.
- W2330260970 cites W1498804420 @default.
- W2330260970 cites W1979988942 @default.
- W2330260970 cites W1982492505 @default.
- W2330260970 cites W2032601470 @default.
- W2330260970 cites W2108818277 @default.
- W2330260970 doi "https://doi.org/10.1016/s0377-1237(05)80200-x" @default.
- W2330260970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4925573" @default.
- W2330260970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27407793" @default.
- W2330260970 hasPublicationYear "2005" @default.
- W2330260970 type Work @default.
- W2330260970 sameAs 2330260970 @default.
- W2330260970 citedByCount "0" @default.
- W2330260970 crossrefType "journal-article" @default.
- W2330260970 hasAuthorship W2330260970A5025849953 @default.
- W2330260970 hasAuthorship W2330260970A5026513387 @default.
- W2330260970 hasAuthorship W2330260970A5055871161 @default.
- W2330260970 hasAuthorship W2330260970A5063242099 @default.
- W2330260970 hasAuthorship W2330260970A5074102236 @default.
- W2330260970 hasBestOaLocation W23302609702 @default.
- W2330260970 hasConcept C104317684 @default.
- W2330260970 hasConcept C114851261 @default.
- W2330260970 hasConcept C133936738 @default.
- W2330260970 hasConcept C167125095 @default.
- W2330260970 hasConcept C176947019 @default.
- W2330260970 hasConcept C2775876089 @default.
- W2330260970 hasConcept C2776021129 @default.
- W2330260970 hasConcept C2778049240 @default.
- W2330260970 hasConcept C2778512257 @default.
- W2330260970 hasConcept C2779607309 @default.
- W2330260970 hasConcept C2779922871 @default.
- W2330260970 hasConcept C2781065037 @default.
- W2330260970 hasConcept C501593827 @default.
- W2330260970 hasConcept C523546767 @default.
- W2330260970 hasConcept C54355233 @default.
- W2330260970 hasConcept C547475151 @default.
- W2330260970 hasConcept C86803240 @default.
- W2330260970 hasConcept C89423630 @default.
- W2330260970 hasConceptScore W2330260970C104317684 @default.
- W2330260970 hasConceptScore W2330260970C114851261 @default.
- W2330260970 hasConceptScore W2330260970C133936738 @default.
- W2330260970 hasConceptScore W2330260970C167125095 @default.
- W2330260970 hasConceptScore W2330260970C176947019 @default.
- W2330260970 hasConceptScore W2330260970C2775876089 @default.
- W2330260970 hasConceptScore W2330260970C2776021129 @default.
- W2330260970 hasConceptScore W2330260970C2778049240 @default.
- W2330260970 hasConceptScore W2330260970C2778512257 @default.
- W2330260970 hasConceptScore W2330260970C2779607309 @default.
- W2330260970 hasConceptScore W2330260970C2779922871 @default.
- W2330260970 hasConceptScore W2330260970C2781065037 @default.
- W2330260970 hasConceptScore W2330260970C501593827 @default.
- W2330260970 hasConceptScore W2330260970C523546767 @default.
- W2330260970 hasConceptScore W2330260970C54355233 @default.
- W2330260970 hasConceptScore W2330260970C547475151 @default.
- W2330260970 hasConceptScore W2330260970C86803240 @default.
- W2330260970 hasConceptScore W2330260970C89423630 @default.
- W2330260970 hasLocation W23302609701 @default.
- W2330260970 hasLocation W23302609702 @default.
- W2330260970 hasLocation W23302609703 @default.
- W2330260970 hasLocation W23302609704 @default.
- W2330260970 hasOpenAccess W2330260970 @default.
- W2330260970 hasPrimaryLocation W23302609701 @default.
- W2330260970 hasRelatedWork W2047269947 @default.
- W2330260970 hasRelatedWork W2082027514 @default.
- W2330260970 hasRelatedWork W2394979363 @default.
- W2330260970 hasRelatedWork W2525700588 @default.
- W2330260970 hasRelatedWork W2549010743 @default.
- W2330260970 hasRelatedWork W2590946279 @default.
- W2330260970 hasRelatedWork W3025849824 @default.
- W2330260970 hasRelatedWork W3048419907 @default.
- W2330260970 hasRelatedWork W3165182985 @default.
- W2330260970 hasRelatedWork W2339789310 @default.
- W2330260970 isParatext "false" @default.
- W2330260970 isRetracted "false" @default.
- W2330260970 magId "2330260970" @default.
- W2330260970 workType "article" @default.