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- W2330304848 abstract "<b>Introduction:</b> No comprehensive meta-analysis has been performed concerning the efficacy and tolerability of adjunctive therapy with histamine-2 receptor antagonists (H<sub>2</sub>R-ANTs) in schizophrenia patients who were treated with antipsychotics. <b>Methods:</b> Risk ratios, standardized mean differences (SMD), and 95% confidence intervals were calculated. <b>Results:</b> We included 8 double-blinded, randomized placebo-controlled trials (RCTs) (n=418) that met the inclusion criteria (famotidine: N=3, n=74; nizatidine: N=4, n=292; ranitidine: N=1, n=52). Pooled H<sub>2</sub>R-ANTs were not different from placebo with regard to reduction in overall symptoms and body weight. However, pooled H<sub>2</sub>R-ANTs resulted in lower body mass index (BMI) than placebo (SMD=−0.68). Moreover, nizatidine was associated with an increase in plasma leptin levels (SMD=− 1.14). There were no significant differences in the discontinuation rates due to all-cause, side effects, and inefficacy between pooled H<sub>2</sub>R-ANTs and placebo. However, nizatidine produced more depression and dry mouth than placebo. <b>Discussion:</b> H<sub>2</sub>R-ANT adjunctive therapy did not improve overall symptoms. To clarify the opposite results between body weight and BMI, future research should investigate long-term efficacy and generate more safety data by using larger samples." @default.
- W2330304848 created "2016-06-24" @default.
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- W2330304848 date "2014-10-16" @default.
- W2330304848 modified "2023-09-27" @default.
- W2330304848 title "Efficacy and Tolerability of Histamine-2 Receptor Antagonist Adjunction of Antipsychotic Treatment in Schizophrenia: A Meta-analysis of Randomized Placebo-controlled Trials" @default.
- W2330304848 doi "https://doi.org/10.1055/s-0034-1390478" @default.
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