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• W2330371568 startingPage "2279" @default.
• W2330371568 abstract "The sensitive detection of highly toxic botulinum neurotoxin (BoNT) from Clostridium botulinum is of critical importance because it causes human illnesses if foodborne or introduced in wounds and as an iatrogenic substance. Moreover, it has been recently considered a possible biological warfare agent. Over the past decade, significant progress has been made in BoNT detection technologies, including mouse lethality assays, enzyme-linked immunosorbent assays, and endopeptidase assays and by mass spectrometry. Critical assay requirements, including rapid assay, active toxin detection, sensitive and accurate detection, still remain challenging. Here, we present a novel method to detect active BoNTs using a Glyco-quantitative polymerase chain-reaction (qPCR) approach. Sialyllactose, which interacts with the binding-domain of BoNTs, is incorporated into a sialyllactose-DNA conjugate as a binding-probe for active BoNT and recovered through BoNT-immunoprecipitation. Glyco-qPCR analysis of the bound sialyllactose-DNA is then used to detect low attomolar concentrations of BoNT and attomolar to femtomolar concentrations of BoNT in honey, the most common foodborne source of infant botulism." @default.
• W2330371568 created "2016-06-24" @default.
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• W2330371568 date "2014-02-24" @default.
• W2330371568 modified "2023-09-26" @default.
• W2330371568 title "High Sensitivity Detection of Active Botulinum Neurotoxin by Glyco-Quantitative Polymerase Chain-Reaction" @default.
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• W2330371568 doi "https://doi.org/10.1021/ac500262d" @default.
• W2330371568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3985614" @default.
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• W2330371568 hasPublicationYear "2014" @default.
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