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- W2330372298 abstract "Diffuse panbronchiolitis (DPB) is a disease with chronic inflammation localized mainly in the region of the respiratory bronchioles. Chronic respiratory infection including Pseudomonas aeruginosa infection is the common complication of DPB in the advanced stage. For the purpose of studying defense mechanisms in DPB patients, peripheral blood B lymphocyte function in 23 DPB patients and in normal controls was evaluated.First, the capacity to generate immunoglobulin secreting cells (Ig SC) in vitro in response to pokeweed mitogen (PWM) and the number of spontaneous Ig SC were evaluated. Peripheral blood mononuclear cells (PBMC) in DPB patients were markedly deficient in their capacity to response to PWM with differentiation of Ig SC. This diminished responsiveness could not be ascribed to the deficiency of helper T cell activity, the presence of increased numbers of cells with suppressive capacity or adherent suppressor cells. DPB patients had significantly higher spontaneous Ig SC than normal controls.Interleukin-1 (IL-1) is a monocyte product with diverse amplifying effects on immune cell responses. The production of IL-1 by monocyte from DPB patients under stimulation of lipopolysaccharide (LPS) was examined. Monocytes from DPB patients produced IL-1 activity not less than those of normal controls.Secondly, the response of B lymphocytes to B cell growth factor (BCGF) and B cell differentiation factor (BCDF) was examined. T cell culture supernatant in healthy volunteers was used as T cell factor containing BCGF and/or BCDF activities. Although B lymphocytes from DPB patients proliferated in response to BCGF in the presence of anti-Ig M stimulation, did not produce Ig G in response to helper T cell factor containing BCGF and BCDF activities.These data indicate us the presence of polyclonal activation of B lymphocytes in vivo in DPB patients. The mechanisms for B cell activation in patients with DPB might be heterogeneous. These findings may contribute the understanding of the immunoregulatory impairment in DPB." @default.
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- W2330372298 date "1985-01-01" @default.
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- W2330372298 title "B lymphocyte function in diffuse panbronchiolitis" @default.
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- W2330372298 doi "https://doi.org/10.2177/jsci.8.336" @default.
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