Matches in SemOpenAlex for { <https://semopenalex.org/work/W233037655> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W233037655 abstract "The overall objective of this project has been to develop immunochemical methods to quantitate unique DNA base damages in order to facilitate studies on radiation-induced damage production and repair. Specifically, we have been using antibodies raised to damaged bases to quantitate unique lesions in model systems in order to evaluate their potential biological consequences. Our approach has been to synthesize modified nucleotides or nucleosides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits or to prepare monoclonal antibodies. We have been studying damages that are stable radiolysis products found in X-irradiated DNA and thus of potential biological consequence. Our aim is to build an in vitro and in vivo data base on the interactions between model DNA lesions and such cellular enzymes as DNA polymerases and repair endonucleases. Initial studies have focused on pyrimidine ring saturation products (thymine glycol.and dihydrothymine), products resulting from ring fragmentation or base loss (urea, {Beta}-ureidoisobutyric acid, abasic sites), 7-hydro-8-oxopurines, and more recently, cytosine radiolysis products. These modified bases serve as useful models for examining the potential lethal and/or mutagenic (carcinogenic) effects of the products of DNA radiolysis." @default.
- W233037655 created "2016-06-24" @default.
- W233037655 creator A5011443633 @default.
- W233037655 creator A5051791551 @default.
- W233037655 date "1992-05-01" @default.
- W233037655 modified "2023-09-24" @default.
- W233037655 title "An immunochemical approach to the study of DNA damage and repair. Technical progress report, May 1, 1989--April 30, 1992" @default.
- W233037655 doi "https://doi.org/10.2172/10185414" @default.
- W233037655 hasPublicationYear "1992" @default.
- W233037655 type Work @default.
- W233037655 sameAs 233037655 @default.
- W233037655 citedByCount "0" @default.
- W233037655 crossrefType "report" @default.
- W233037655 hasAuthorship W233037655A5011443633 @default.
- W233037655 hasAuthorship W233037655A5051791551 @default.
- W233037655 hasBestOaLocation W2330376553 @default.
- W233037655 hasConcept C134935766 @default.
- W233037655 hasConcept C139066938 @default.
- W233037655 hasConcept C143425029 @default.
- W233037655 hasConcept C185592680 @default.
- W233037655 hasConcept C2776023528 @default.
- W233037655 hasConcept C2776858809 @default.
- W233037655 hasConcept C2779321679 @default.
- W233037655 hasConcept C34737976 @default.
- W233037655 hasConcept C552990157 @default.
- W233037655 hasConcept C55493867 @default.
- W233037655 hasConcept C66887884 @default.
- W233037655 hasConceptScore W233037655C134935766 @default.
- W233037655 hasConceptScore W233037655C139066938 @default.
- W233037655 hasConceptScore W233037655C143425029 @default.
- W233037655 hasConceptScore W233037655C185592680 @default.
- W233037655 hasConceptScore W233037655C2776023528 @default.
- W233037655 hasConceptScore W233037655C2776858809 @default.
- W233037655 hasConceptScore W233037655C2779321679 @default.
- W233037655 hasConceptScore W233037655C34737976 @default.
- W233037655 hasConceptScore W233037655C552990157 @default.
- W233037655 hasConceptScore W233037655C55493867 @default.
- W233037655 hasConceptScore W233037655C66887884 @default.
- W233037655 hasLocation W2330376551 @default.
- W233037655 hasLocation W2330376552 @default.
- W233037655 hasLocation W2330376553 @default.
- W233037655 hasOpenAccess W233037655 @default.
- W233037655 hasPrimaryLocation W2330376551 @default.
- W233037655 hasRelatedWork W1967295691 @default.
- W233037655 hasRelatedWork W1979923522 @default.
- W233037655 hasRelatedWork W1995490997 @default.
- W233037655 hasRelatedWork W2023347967 @default.
- W233037655 hasRelatedWork W2034282446 @default.
- W233037655 hasRelatedWork W2052140586 @default.
- W233037655 hasRelatedWork W2080648671 @default.
- W233037655 hasRelatedWork W2091594449 @default.
- W233037655 hasRelatedWork W2197255216 @default.
- W233037655 hasRelatedWork W2505695962 @default.
- W233037655 isParatext "false" @default.
- W233037655 isRetracted "false" @default.
- W233037655 magId "233037655" @default.
- W233037655 workType "report" @default.